The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Hdel sequence     (2S)-2-[[(2S)-2-[[(2S)-2- [[(2S)-2-amino-3...

Synonyms: AC1L2YLC, 129623-52-5, His-asp-glu-leu, Histidyl-aspartyl-glutamyl-leucine
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Histidyl-aspartyl-glutamyl-leucine

  • Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually Lys-Asp-Glu-Leu (KDEL in the single letter code) in animal cells, His-Asp-Glu-Leu (HDEL) in Saccharomyces cerevisiae [1].
  • The ERD2 gene, which encodes the yeast HDEL (His-Asp-Glu-Leu) receptor, is essential for growth (Semenza, J. C., K. G. Hardwick, N. Dean, and H. R. B. Pelham. 1990. Cell. 61:1349-1357; Lewis, M. J., D. J. Sweet, and H. R. B. Pelham. 1990. Cell. 61:1359-1363) [2].
  • The HDEL sequence of Sec20p is not essential for viability but helps to maintain intracellular levels of the protein [3].
  • The gene products of all the cloned members of this family contain a carboxy-terminal His-Asp-Glu-Leu peptide that may form the signal for retention in the endoplasmic reticulum [4].
  • Electrophysiological studies using 80K-H mutants showed that three domains of 80K-H (the two EF-hand structures, the highly acidic glutamic stretch, and the His-Asp-Glu-Leu sequence) are critical determinants for TRPV5 activity [5].

Biological context of Histidyl-aspartyl-glutamyl-leucine


Gene context of Histidyl-aspartyl-glutamyl-leucine


Analytical, diagnostic and therapeutic context of Histidyl-aspartyl-glutamyl-leucine


  1. A human homologue of the yeast HDEL receptor. Lewis, M.J., Pelham, H.R. Nature (1990) [Pubmed]
  2. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. Hardwick, K.G., Pelham, H.R. J. Cell Biol. (1992) [Pubmed]
  3. The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system. Sweet, D.J., Pelham, H.R. EMBO J. (1992) [Pubmed]
  4. The tobacco luminal binding protein is encoded by a multigene family. Denecke, J., Goldman, M.H., Demolder, J., Seurinck, J., Botterman, J. Plant Cell (1991) [Pubmed]
  5. 80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5). Gkika, D., Mahieu, F., Nilius, B., Hoenderop, J.G., Bindels, R.J. J. Biol. Chem. (2004) [Pubmed]
  6. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. Weis, K., Griffiths, G., Lamond, A.I. J. Biol. Chem. (1994) [Pubmed]
  7. Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. Ozawa, M., Muramatsu, T. J. Biol. Chem. (1993) [Pubmed]
  8. Endoplasmic reticulum preprophase band in dividing root-tip cells of Pinus brutia. Zachariadis, M., Quader, H., Galatis, B., Apostolakos, P. Planta (2001) [Pubmed]
  9. Two distinct domains of the beta-subunit of glucosidase II interact with the catalytic alpha-subunit. Arendt, C.W., Ostergaard, H.L. Glycobiology (2000) [Pubmed]
  10. A mutant Kex2 enzyme with a C-terminal HDEL sequence releases correctly folded human insulin-like growth factor-1 from a precursor accumulated in the yeast endoplasmic reticulum. Chaudhuri, B., Latham, S.E., Stephan, C. Eur. J. Biochem. (1992) [Pubmed]
  11. Overexpression of protein disulfide isomerase in Aspergillus. El-Adawi, H., Khanh, N.Q., Gassen, H. Curr. Microbiol. (2000) [Pubmed]
  12. Endoplasmic reticulum subcompartments in a plant parasitic fungus and in baker's yeast: differential distribution of lumenal proteins. Bachem, U., Mendgen, K. Exp. Mycol. (1995) [Pubmed]
WikiGenes - Universities