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Hdel sequence     (2S)-2-[[(2S)-2-[[(2S)-2- [[(2S)-2-amino-3...

Synonyms: AC1L2YLC, 129623-52-5, His-asp-glu-leu, Histidyl-aspartyl-glutamyl-leucine
 
 
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High impact information on Histidyl-aspartyl-glutamyl-leucine

  • Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually Lys-Asp-Glu-Leu (KDEL in the single letter code) in animal cells, His-Asp-Glu-Leu (HDEL) in Saccharomyces cerevisiae [1].
  • The ERD2 gene, which encodes the yeast HDEL (His-Asp-Glu-Leu) receptor, is essential for growth (Semenza, J. C., K. G. Hardwick, N. Dean, and H. R. B. Pelham. 1990. Cell. 61:1349-1357; Lewis, M. J., D. J. Sweet, and H. R. B. Pelham. 1990. Cell. 61:1359-1363) [2].
  • The HDEL sequence of Sec20p is not essential for viability but helps to maintain intracellular levels of the protein [3].
  • The gene products of all the cloned members of this family contain a carboxy-terminal His-Asp-Glu-Leu peptide that may form the signal for retention in the endoplasmic reticulum [4].
  • Electrophysiological studies using 80K-H mutants showed that three domains of 80K-H (the two EF-hand structures, the highly acidic glutamic stretch, and the His-Asp-Glu-Leu sequence) are critical determinants for TRPV5 activity [5].
 

Biological context of Histidyl-aspartyl-glutamyl-leucine

 

Gene context of Histidyl-aspartyl-glutamyl-leucine

 

Analytical, diagnostic and therapeutic context of Histidyl-aspartyl-glutamyl-leucine

References

  1. A human homologue of the yeast HDEL receptor. Lewis, M.J., Pelham, H.R. Nature (1990) [Pubmed]
  2. SED5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. Hardwick, K.G., Pelham, H.R. J. Cell Biol. (1992) [Pubmed]
  3. The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system. Sweet, D.J., Pelham, H.R. EMBO J. (1992) [Pubmed]
  4. The tobacco luminal binding protein is encoded by a multigene family. Denecke, J., Goldman, M.H., Demolder, J., Seurinck, J., Botterman, J. Plant Cell (1991) [Pubmed]
  5. 80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5). Gkika, D., Mahieu, F., Nilius, B., Hoenderop, J.G., Bindels, R.J. J. Biol. Chem. (2004) [Pubmed]
  6. The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. Weis, K., Griffiths, G., Lamond, A.I. J. Biol. Chem. (1994) [Pubmed]
  7. Reticulocalbin, a novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs and a carboxyl-terminal HDEL sequence. Ozawa, M., Muramatsu, T. J. Biol. Chem. (1993) [Pubmed]
  8. Endoplasmic reticulum preprophase band in dividing root-tip cells of Pinus brutia. Zachariadis, M., Quader, H., Galatis, B., Apostolakos, P. Planta (2001) [Pubmed]
  9. Two distinct domains of the beta-subunit of glucosidase II interact with the catalytic alpha-subunit. Arendt, C.W., Ostergaard, H.L. Glycobiology (2000) [Pubmed]
  10. A mutant Kex2 enzyme with a C-terminal HDEL sequence releases correctly folded human insulin-like growth factor-1 from a precursor accumulated in the yeast endoplasmic reticulum. Chaudhuri, B., Latham, S.E., Stephan, C. Eur. J. Biochem. (1992) [Pubmed]
  11. Overexpression of protein disulfide isomerase in Aspergillus. El-Adawi, H., Khanh, N.Q., Gassen, H. Curr. Microbiol. (2000) [Pubmed]
  12. Endoplasmic reticulum subcompartments in a plant parasitic fungus and in baker's yeast: differential distribution of lumenal proteins. Bachem, U., Mendgen, K. Exp. Mycol. (1995) [Pubmed]
 
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