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Gene Review:

TAF5 - TAF5 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: TAF(II)100, TAF2D, TAFII-100, TAFII100, Transcription initiation factor TFIID 100 kDa subunit, ...

Tao, Y. et al., Dubrovskaya, V. et al., Walker, A.K. et al., Furukawa, T. et al., Ogryzko, V.V. et al., et al.

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High impact information on TAF5

Moreover, the PCAF complex has a novel subunit with WD40 repeats having a similarity to hTAF(II)100 [1].
The broad involvement of TAF-5 in mRNA transcription in vivo suggests a requirement for either TFIID or a TFTC-like complex [2].
Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100 [3].

Biological context of TAF5

Localization of the gene (TAF2D) encoding the 100-kDa subunit (hTAFII100) of the human TFIID complex to chromosome 10 band q24-q25.2 [4].
By contrast, hTAF(II)130 stabilized binding of hTBP to the TATA box, whereas hTAF(II)100 had little effect [5].

Other interactions of TAF5

Immunoprecipitation studies demonstrate that hTAFII100 is an integral subunit that is associated with all transcriptionally-competent forms of TFIID [6].

References

Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko, V.V., Kotani, T., Zhang, X., Schiltz, R.L., Howard, T., Yang, X.J., Howard, B.H., Qin, J., Nakatani, Y. Cell (1998) [Pubmed]
Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. Walker, A.K., Rothman, J.H., Shi, Y., Blackwell, T.K. EMBO J. (2001) [Pubmed]
Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. Tanese, N., Saluja, D., Vassallo, M.F., Chen, J.L., Admon, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Localization of the gene (TAF2D) encoding the 100-kDa subunit (hTAFII100) of the human TFIID complex to chromosome 10 band q24-q25.2. Dubrovskaya, V., Mattei, M.G., Tora, L. Genomics (1996) [Pubmed]
Assembly of partial TFIID complexes in mammalian cells reveals distinct activities associated with individual TATA box-binding protein-associated factors. Furukawa, T., Tanese, N. J. Biol. Chem. (2000) [Pubmed]
Specific interactions and potential functions of human TAFII100. Tao, Y., Guermah, M., Martinez, E., Oelgeschläger, T., Hasegawa, S., Takada, R., Yamamoto, T., Horikoshi, M., Roeder, R.G. J. Biol. Chem. (1997) [Pubmed]

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