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Gene Review

Taf5  -  TBP-associated factor 5

Drosophila melanogaster

Synonyms: CG7704, Dmel\CG7704, TAF, TAF5, TAF80, ...
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High impact information on Taf5

  • Purified recombinant dTAFII80 is unable to bind TBP directly or to interact strongly with the C-terminal domain of dTAFII250 (delta N250) [1].
  • We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAFII80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins [2].
  • Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation [3].
  • To further understand the role of the 85-kDa TFIID subunit (p85), we have cloned the corresponding cDNA with a probe based on an amino acid sequence of the purified protein [4].
  • Yeast TFIID comprises the TATA binding protein and 14 TBP-associated factors (TAF(II)s), nine of which contain histone-fold domains (HFDs) [5].

Biological context of Taf5


Analytical, diagnostic and therapeutic context of Taf5


  1. The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats. Dynlacht, B.D., Weinzierl, R.O., Admon, A., Tjian, R. Nature (1993) [Pubmed]
  2. The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family. Gutjahr, T., Frei, E., Spicer, C., Baumgartner, S., White, R.A., Noll, M. EMBO J. (1995) [Pubmed]
  3. Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. Klemm, R.D., Goodrich, J.A., Zhou, S., Tjian, R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunit. Kokubo, T., Gong, D.W., Yamashita, S., Takada, R., Roeder, R.G., Horikoshi, M., Nakatani, Y. Mol. Cell. Biol. (1993) [Pubmed]
  5. Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain. Thuault, S., Gangloff, Y.G., Kirchner, J., Sanders, S., Werten, S., Romier, C., Weil, P.A., Davidson, I. J. Biol. Chem. (2002) [Pubmed]
  6. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. MacDougall, L.K., Domin, J., Waterfield, M.D. Curr. Biol. (1995) [Pubmed]
  7. Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo. Keaveney, M., Struhl, K. Genes Cells (1999) [Pubmed]
  8. Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Albert, S., Twardzik, T., Heisenberg, M., Schneuwly, S. Gene (1997) [Pubmed]
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