Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TBX6 - T-box 6

Homo sapiens

Synonyms: T-box protein 6, T-box transcription factor TBX6

Takahashi, H. et al., Hofmann, M. et al., Papapetrou, C. et al.

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High impact information on TBX6

WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos [1].
The human TBX6 gene: cloning and assignment to chromosome 16p11.2 [2].
In the ascidian Halocynthia roretzi, Brachyury (HrBra) is expressed only in notochord cells while Tbx6 (HrTbx6) is expressed in muscle cells [3].

References

WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Hofmann, M., Schuster-Gossler, K., Watabe-Rudolph, M., Aulehla, A., Herrmann, B.G., Gossler, A. Genes Dev. (2004) [Pubmed]
The human TBX6 gene: cloning and assignment to chromosome 16p11.2. Papapetrou, C., Putt, W., Fox, M., Edwards, Y.H. Genomics (1999) [Pubmed]
Both the functional specificity and autoregulative activity of two ascidian T-box genes HrBra and HrTbx6 are likely to be mediated by the DNA-binding domain. Takahashi, H., Mitani, Y., Satoh, N. Dev. Growth Differ. (2005) [Pubmed]

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