Gene Review:
Pir - pirin
Mus musculus
Synonyms:
2310042L19Rik, Pirin, Pirnl, iron-binding nuclear protein
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High impact information on Pir
- Multiple Pirin transcripts are expressed in skeletal muscle and heart [1].
- Genomic Southern and Western blots demonstrate the presence of Pirin genes and their expression, respectively, in all mammalian cell lines tested [1].
- About 15% of all Pirin cDNAs contain a short 34-base pair insertion in their 5'-untranslated regions, indicative of alternative splicing processes [1].
Analytical, diagnostic and therapeutic context of Pir
- In this article we describe the molecular cloning of Pirin, a novel highly conserved 32-kDa protein consisting of 290 amino acids [1].
- Moreover, confocal immunofluorescence experiments demonstrate a predominant localization of Pirin within dot-like subnuclear structures [1].
- Western blots and immunoprecipitations employing monoclonal anti-Pirin antibodies reveal that Pirin is a nuclear protein [1].
References
- Identification of pirin, a novel highly conserved nuclear protein. Wendler, W.M., Kremmer, E., Förster, R., Winnacker, E.L. J. Biol. Chem. (1997) [Pubmed]
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