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Pir  -  pirin (iron-binding nuclear protein)

Rattus norvegicus

Synonyms: Pirin
 
 
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High impact information on Pir

  • The expression of pirin, a nuclear factor I-interacting protein, was lowered after inhibition of MEK1 [1].
  • Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts [1].
  • The highest laminar density was that of layer I in all regions except Pir, but each region had a distinct pattern of 5-HT innervation [2].
  • RESULTS: Atropine (Atr, 0.029-2.9 mumol.L-1), 4-DAMP (3.6-360 nmol.L-1), pirenzepine (Pir, 0.23-23.5 mumol.L-1), and AF-DX 116 (0.7-35.6 mumol.L-1) competitively antagonized the muscular uterine concentration induced by ACh (0.068-36068 mumol.L-1) [3].
 

Associations of Pir with chemical compounds

  • The pKB and slopes values (95% confidence limits) were 9.28 +/- 0.12 and 1.00 +/- 0.10 to Atr, 9.06 +/- 0.10 and 1.10 +/- 0.08 to 4-DAMP, 7.03 +/- 0.15 and 0.99 +/- 0.12 to Pir, and 5.60 +/- 0.08 and 1.00 +/- 0.19 to AF-DX 116 [3].
 

Analytical, diagnostic and therapeutic context of Pir

  • Western blot analysis revealed increased expression of pirin in RAS and c-JUN transformed cells in the absence of PD98059 [1].

References

  1. Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts. Bergman, A.C., Alaiya, A.A., Wendler, W., Binetruy, B., Shoshan, M., Sakaguchi, K., Bergman, T., Kronenwett, U., Auer, G., Appella, E., Jörnvall, H., Linder, S. Cell. Mol. Life Sci. (1999) [Pubmed]
  2. Quantified regional and laminar distribution of the serotonin innervation in the anterior half of adult rat cerebral cortex. Audet, M.A., Descarries, L., Doucet, G. J. Chem. Neuroanat. (1989) [Pubmed]
  3. Antagonistic effects of trifluoperazine, imipramine, and chlorpromazine against acetylcholine-induced contractions in isolated rat uterus. Balais, S.Y., Prado, W.A., Alves-do-Prado, W. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1997) [Pubmed]
 
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