The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Degs2  -  degenerative spermatocyte homolog 2...

Mus musculus

Synonyms: 2210008A03Rik, AI852933, DES2, Degenerative spermatocyte homolog 2, Des2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Degs2

  • Transcript levels of Des-2, but not Des-1, were considerably decreased in cultured keratinocytes from Arnt-null epidermis [1].
  • Although the amino acid sequences of mouse DES1 (MDES1) and DES2 (MDES2) have 63% sequence identity, their enzymatic characteristics are quite different [2].
  • However, compared with 0 DES2, 10(-7) M DES reduced (P less than .05) the number of swine blastocysts developing from one- to two-cell (36 vs 78%) and three- to four-cell embryos (50 vs 84%) [3].
  • Des2 (degenerative spermatocyte 2) is a bifunctional enzyme that produces phytoceramide and ceramide from dihydroceramide [4].
  • The findings of the present study indicate that the hydroxylation requires complex formation between Des2 and mb5 via their membrane-spanning domains and electron transfer from NADH to the substrate via the reduction of mb5 by b5R [4].
 

Biological context of Degs2

  • FLAG-tagged mouse Des2 was expressed in insect Sf9 cells and was purified by solubilization with digitonin and anti-FLAG antibody affinity column chromatography [4].
 

Anatomical context of Degs2

References

  1. Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. Takagi, S., Tojo, H., Tomita, S., Sano, S., Itami, S., Hara, M., Inoue, S., Horie, K., Kondoh, G., Hosokawa, K., Gonzalez, F.J., Takeda, J. J. Clin. Invest. (2003) [Pubmed]
  2. Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2. Omae, F., Miyazaki, M., Enomoto, A., Suzuki, A. FEBS Lett. (2004) [Pubmed]
  3. Suppressed development of cultured mouse and swine embryos by diethylstilbestrol. Gardiner, C.S., Menino, A.R., Archibong, A.E., Williams, J.S., Stormshak, F., England, D.C. J. Anim. Sci. (1988) [Pubmed]
  4. Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5. Enomoto, A., Omae, F., Miyazaki, M., Kozutsumi, Y., Yubisui, T., Suzuki, A. Biochem. J. (2006) [Pubmed]
  5. DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. Omae, F., Miyazaki, M., Enomoto, A., Suzuki, M., Suzuki, Y., Suzuki, A. Biochem. J. (2004) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities