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Gene Review

ifc  -  infertile crescent

Drosophila melanogaster

Synonyms: CG9078, DES-1, Dmel\CG9078, Ifc, des, ...
 
 
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Disease relevance of ifc

 

High impact information on ifc

  • This mutant phenotype can be restored to wild-type by complementation with a functional copy of the des gene (Endo, K., Akiyama, T., Kobayashi S., and Okada, M. (1996) Mol. Gen. Genet. 253, 157-165) [1].
  • We have identified a novel Drosophila gene, degenerative spermatocyte (des), that may be required for the initiation of meiosis in spermatogenesis [2].
  • In des mutant testes, the primary spermatocytes become mature in size but degenerate without initiating meiotic chromosome condensation in their nuclei [2].
  • We have mapped the locus of the des gene at 26A on the left arm of the second chromosome, and identified two related, differentially spliced transcripts (des-1, des-2) from the locus [2].
 

Biological context of ifc

 

Anatomical context of ifc

  • These results raise the possibility that the des gene product may be required for interactions between primary spermatocytes and surrounding somatic cells [2].
  • The expression of the des-1 transcript is significantly suppressed in the des mutant testes, whereas expression of the des-2 transcript is undetectable in both wild-type and mutant testes, indicating that the des-1 transcript encodes the des function in spermatogenesis [2].

References

  1. Identification and characterization of a sphingolipid delta 4-desaturase family. Ternes, P., Franke, S., Zähringer, U., Sperling, P., Heinz, E. J. Biol. Chem. (2002) [Pubmed]
  2. Degenerative spermatocyte, a novel gene encoding a transmembrane protein required for the initiation of meiosis in Drosophila spermatogenesis. Endo, K., Akiyama, T., Kobayashi, S., Okada, M. Mol. Gen. Genet. (1996) [Pubmed]
 
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