The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ifc  -  infertile crescent

Drosophila melanogaster

Synonyms: CG9078, DES-1, Dmel\CG9078, Ifc, des, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ifc


High impact information on ifc

  • This mutant phenotype can be restored to wild-type by complementation with a functional copy of the des gene (Endo, K., Akiyama, T., Kobayashi S., and Okada, M. (1996) Mol. Gen. Genet. 253, 157-165) [1].
  • We have identified a novel Drosophila gene, degenerative spermatocyte (des), that may be required for the initiation of meiosis in spermatogenesis [2].
  • In des mutant testes, the primary spermatocytes become mature in size but degenerate without initiating meiotic chromosome condensation in their nuclei [2].
  • We have mapped the locus of the des gene at 26A on the left arm of the second chromosome, and identified two related, differentially spliced transcripts (des-1, des-2) from the locus [2].

Biological context of ifc


Anatomical context of ifc

  • These results raise the possibility that the des gene product may be required for interactions between primary spermatocytes and surrounding somatic cells [2].
  • The expression of the des-1 transcript is significantly suppressed in the des mutant testes, whereas expression of the des-2 transcript is undetectable in both wild-type and mutant testes, indicating that the des-1 transcript encodes the des function in spermatogenesis [2].


  1. Identification and characterization of a sphingolipid delta 4-desaturase family. Ternes, P., Franke, S., Zähringer, U., Sperling, P., Heinz, E. J. Biol. Chem. (2002) [Pubmed]
  2. Degenerative spermatocyte, a novel gene encoding a transmembrane protein required for the initiation of meiosis in Drosophila spermatogenesis. Endo, K., Akiyama, T., Kobayashi, S., Okada, M. Mol. Gen. Genet. (1996) [Pubmed]
WikiGenes - Universities