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Gene Review:

Ifih1 - interferon induced with helicase C domain 1

Mus musculus

Synonyms: 9130009C22Rik, Helicard, Helicase with 2 CARD domains, Hlcd, Interferon induced with helicase C domain protein 1, ...

Kumar, H. et al., Kato, H. et al., Yoneyama, M. et al., Stetson, D.B. et al.

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Disease relevance of Ifih1

Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses [1].
We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection [2].
The nonstructural protein 3/4A protein of hepatitis C virus blocks the signaling by RIG-I and MDA5; however, the V protein of the Sendai virus selectively abrogates the MDA5 function [3].

High impact information on Ifih1

Microarray analyses reveal a unique but overlapping gene-expression program activated by cytosolic DNA compared to TLR9- and RIG-I/MDA5-dependent responses [4].
IFN-beta promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses [1].

References

Essential role of IPS-1 in innate immune responses against RNA viruses. Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K.J., Takeuchi, O., Akira, S. J. Exp. Med. (2006) [Pubmed]
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K.J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.S., Reis e Sousa, C., Matsuura, Y., Fujita, T., Akira, S. Nature (2006) [Pubmed]
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y.M., Gale, M., Akira, S., Yonehara, S., Kato, A., Fujita, T. J. Immunol. (2005) [Pubmed]
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Stetson, D.B., Medzhitov, R. Immunity (2006) [Pubmed]

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