Disease relevance of Senp8

• In the present study, we compare the role of nonspecific helper factors produced by Den-1 (Den-1 SN) or the T cell thymoma EL4 (EL4-SN) in promotion of B cell plaque-forming cell (PFC) responses to a variety of antigens [1].

High impact information on Senp8

• Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators [2].
• We described a cloned dendritic cell, clone Den-1, that is a potent accessory cell for some B cell responses [1].
• B cell PFC responses to TNP-Brucella abortus (BA) and TNP-lipopolysaccharide (LPS) are greatly increased by EL4-SN but show little, if any, enhancement with Den-1 SN [1].
• In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells [3].

Anatomical context of Senp8

• Clone Den-1 produces a novel lymphokine that is distinct from previously described factors produced by T cells [1].
• We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses [3].

Analytical, diagnostic and therapeutic context of Senp8

• Clone Den-1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co-recognize nominal antigen plus I-Ab gene products [3].

References