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Gene Review

Senp8  -  SUMO/sentrin specific peptidase 8

Mus musculus

Synonyms: 9130010J17Rik, AU020827, Den1, Deneddylase-1, NEDD8-specific protease 1, ...
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Disease relevance of Senp8

  • In the present study, we compare the role of nonspecific helper factors produced by Den-1 (Den-1 SN) or the T cell thymoma EL4 (EL4-SN) in promotion of B cell plaque-forming cell (PFC) responses to a variety of antigens [1].

High impact information on Senp8

  • Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators [2].
  • We described a cloned dendritic cell, clone Den-1, that is a potent accessory cell for some B cell responses [1].
  • B cell PFC responses to TNP-Brucella abortus (BA) and TNP-lipopolysaccharide (LPS) are greatly increased by EL4-SN but show little, if any, enhancement with Den-1 SN [1].
  • In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells [3].

Anatomical context of Senp8

  • Clone Den-1 produces a novel lymphokine that is distinct from previously described factors produced by T cells [1].
  • We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses [3].

Analytical, diagnostic and therapeutic context of Senp8


  1. B cell activation: role of dendritic and T cell factors in the response to thymic-independent and -dependent antigens. DeKruyff, R., Clayberger, C., Fay, R., Cantor, H. J. Immunol. (1985) [Pubmed]
  2. Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell. Clayberger, C., DeKruyff, R.H., Fay, R., Cantor, H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Immunoregulation of T-dependent responses by a cloned dendritic cell. Clayberger, C., DeKruyff, R.H., Fay, R., Pavlakis, M., Cantor, H. J. Immunol. (1984) [Pubmed]
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