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Gene Review:

Xpo5 - exportin 5

Mus musculus

Synonyms: 2410004H11Rik, 2700038C24Rik, AI648907, AW549301, Exp5, ...

Grimm, D. et al., Tampellini, M. et al., Fok, V. et al.

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Disease relevance of Xpo5

In Exp 5 to 7, docetaxel was administered to mice bearing measurable P03 pancreatic adenocarcinoma (270-370 mg), with tumor weight and survival as endpoints [1].

High impact information on Xpo5

EBER1 does not bind exportin 5; therefore, it is unlikely to act by interfering with microRNA biogenesis [2].
In vitro and in vivo shRNA transfection studies implied that one such factor, shared by the shRNA/miRNA pathways and readily saturated, is the nuclear karyopherin exportin-5 [3].

References

Docetaxel chronopharmacology in mice. Tampellini, M., Filipski, E., Liu, X.H., Lemaigre, G., Li, X.M., Vrignaud, P., François, E., Bissery, M.C., Lévi, F. Cancer Res. (1998) [Pubmed]
Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. Fok, V., Friend, K., Steitz, J.A. J. Cell Biol. (2006) [Pubmed]
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F., Kay, M.A. Nature (2006) [Pubmed]

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HST	Arabidopsis thaliana
XPO5	Bos taurus
XPO5	Canis lupus familiaris
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XPO5	Gallus gallus
XPO5	Homo sapiens
XPO5	Macaca mulatta
Os01g0363900	Oryza sativa Japonica Group
XPO5	Pan troglodytes
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xpo5	Xenopus (Silurana) tropicalis

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