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Gene Review

Xpo5  -  exportin 5

Mus musculus

Synonyms: 2410004H11Rik, 2700038C24Rik, AI648907, AW549301, Exp5, ...
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Disease relevance of Xpo5


High impact information on Xpo5

  • EBER1 does not bind exportin 5; therefore, it is unlikely to act by interfering with microRNA biogenesis [2].
  • In vitro and in vivo shRNA transfection studies implied that one such factor, shared by the shRNA/miRNA pathways and readily saturated, is the nuclear karyopherin exportin-5 [3].


  1. Docetaxel chronopharmacology in mice. Tampellini, M., Filipski, E., Liu, X.H., Lemaigre, G., Li, X.M., Vrignaud, P., François, E., Bissery, M.C., Lévi, F. Cancer Res. (1998) [Pubmed]
  2. Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. Fok, V., Friend, K., Steitz, J.A. J. Cell Biol. (2006) [Pubmed]
  3. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F., Kay, M.A. Nature (2006) [Pubmed]
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