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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HST  -  protein HASTY

Arabidopsis thaliana

Synonyms: HASTY, HASTY 1, HST1, T9J14.1, T9J14_1
 
 
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High impact information on HST

  • In this study, we examined the function of HASTY (HST), the Arabidopsis ortholog of Exp5, in the biogenesis of miRNAs and tRNAs [1].
  • Interestingly, loss-of-function mutations in HST reduced the accumulation of most miRNAs but had no effect on the accumulation of tRNAs and endogenous small interfering RNAs, or on transgene silencing [1].
  • These results demonstrate that HST and PSD do not share RNA cargos in nuclear export and strongly suggest that there are multiple nuclear export pathways for these small RNAs in Arabidopsis [1].
  • Consistent with a potential role in nucleocytoplasmic transport, we found that HST interacts with RAN1 in a yeast two-hybrid assay and that a HST-GUS fusion protein is located at the periphery of the nucleus [2].
  • Double mutant analysis suggests that HST acts in parallel to SQUINT in the regulation of phase change and in parallel to KANADI in the regulation of leaf polarity [2].

References

  1. Nuclear processing and export of microRNAs in Arabidopsis. Park, M.Y., Wu, G., Gonzalez-Sulser, A., Vaucheret, H., Poethig, R.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis. Bollman, K.M., Aukerman, M.J., Park, M.Y., Hunter, C., Berardini, T.Z., Poethig, R.S. Development (2003) [Pubmed]
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