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Gene Review

XPO5  -  exportin 5

Homo sapiens

Synonyms: Exp5, Exportin-5, KIAA1291, RANBP21, Ran-binding protein 21
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High impact information on XPO5


Biological context of XPO5


Anatomical context of XPO5

  • The knockdown of Drosophila exportin-5 in cultured cells decreased the amounts of tRNA as well as miRNA, whereas the knock down of human exportin-5 in cultured cells affected only miRNA but not tRNA levels [9].

Associations of XPO5 with chemical compounds

  • Exp5 binds correctly processed pre-miRNAs directly and specifically, in a Ran guanosine triphosphate-dependent manner, but interacts only weakly with extended pre-miRNAs that yield incorrect miRNAs when processed by Dicer in vitro [10].
  • Of the five expansin genes expressed in control roots, two alpha-expansins (Exp1 and Exp5) and two beta-expansins (ExpB2 and ExpB8) are expressed specifically in the growing region, whereas expression of beta-expansin ExpB6 is shifted basipetally [11].

Physical interactions of XPO5


Regulatory relationships of XPO5


Other interactions of XPO5

  • Together, these data suggest that JAZ is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism [5].
  • Formation of this complex is facilitated by the ability of both exportin-5 and ILF3 to mutually increase their apparent affinity for VA1 RNA [6].
  • These results indicate that double-stranded RNA binding ability is an inherited functional characteristic of the exportin-5 orthologues and that Drosophila exportin-5 functions as an exporter of tRNAs as well as pre-miRNAs in the fruit fly that lacks the orthologous gene for exportin-t [9].
  • Exportin-5, an evolutionarily conserved nuclear export factor belonging to the importin-beta family of proteins, is known to play a role in the nuclear export of small noncoding RNAs such as precursors of microRNA, viral minihelix RNA and a subset of tRNAs in mammalian cells [9].
  • The discrepancy between pri-miRNA and miR expression following overload was not explained by a change in the expression of components of the miRNA biogenesis pathway, since Drosha and Exportin-5 transcript levels were significantly increased by 50% in response to functional overload, whereas Dicer expression remained unchanged [12].

Analytical, diagnostic and therapeutic context of XPO5


  1. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Murchison, E.P., Hannon, G.J. Curr. Opin. Cell Biol. (2004) [Pubmed]
  2. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Yi, R., Qin, Y., Macara, I.G., Cullen, B.R. Genes Dev. (2003) [Pubmed]
  3. Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. Fok, V., Friend, K., Steitz, J.A. J. Cell Biol. (2006) [Pubmed]
  4. Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. Calado, A., Treichel, N., Müller, E.C., Otto, A., Kutay, U. EMBO J. (2002) [Pubmed]
  5. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. Chen, T., Brownawell, A.M., Macara, I.G. Mol. Cell. Biol. (2004) [Pubmed]
  6. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. Gwizdek, C., Ossareh-Nazari, B., Brownawell, A.M., Evers, S., Macara, I.G., Dargemont, C. J. Biol. Chem. (2004) [Pubmed]
  7. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Screaton, R.A., Kiessling, S., Sansom, O.J., Millar, C.B., Maddison, K., Bird, A., Clarke, A.R., Frisch, S.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. Yi, R., Doehle, B.P., Qin, Y., Macara, I.G., Cullen, B.R. RNA (2005) [Pubmed]
  9. Exportin-5 orthologues are functionally divergent among species. Shibata, S., Sasaki, M., Miki, T., Shimamoto, A., Furuichi, Y., Katahira, J., Yoneda, Y. Nucleic Acids Res. (2006) [Pubmed]
  10. Nuclear export of microRNA precursors. Lund, E., Güttinger, S., Calado, A., Dahlberg, J.E., Kutay, U. Science (2004) [Pubmed]
  11. Modification of expansin transcript levels in the maize primary root at low water potentials. Wu, Y., Thorne, E.T., Sharp, R.E., Cosgrove, D.J. Plant Physiol. (2001) [Pubmed]
  12. MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. McCarthy, J.J., Esser, K.A. J. Appl. Physiol. (2007) [Pubmed]
  13. Exportin-5 mediates nuclear export of minihelix-containing RNAs. Gwizdek, C., Ossareh-Nazari, B., Brownawell, A.M., Doglio, A., Bertrand, E., Macara, I.G., Dargemont, C. J. Biol. Chem. (2003) [Pubmed]
  14. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. Bohnsack, M.T., Czaplinski, K., Gorlich, D. RNA (2004) [Pubmed]
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