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Gene Review

UQCRH  -  ubiquinol-cytochrome c reductase hinge...

Homo sapiens

Synonyms: Complex III subunit 6, Complex III subunit VIII, Cytochrome b-c1 complex subunit 6, mitochondrial, Cytochrome c1 non-heme 11 kDa protein, Mitochondrial hinge protein, ...
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Disease relevance of UQCRH


High impact information on UQCRH

  • All the three breakpoints, two on 22q12 and one in 1p34, interrupt different genes: EWS, ZSG and UQCRH [1].
  • We determined the genomic structure of UQCRH, characterized its splicing variants and identified a transcribed processed pseudogene [1].

Analytical, diagnostic and therapeutic context of UQCRH


  1. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. Modena, P., Testi, M.A., Facchinetti, F., Mezzanzanica, D., Radice, M.T., Pilotti, S., Sozzi, G. Oncogene (2003) [Pubmed]
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