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PATZ1  -  POZ (BTB) and AT hook containing zinc...

Homo sapiens

Synonyms: BTB/POZ domain zinc finger transcription factor, MAZR, PATZ, POZ-, AT hook-, and zinc finger-containing protein 1, Protein kinase A RI subunit alpha-associated protein, ...
 
 
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Disease relevance of PATZ1

  • We previously reported the identification of a novel zinc-finger gene, designated ZSG, fused to Ewing sarcoma gene (EWS) by a submicroscopic paracentric inversion of 22q12 in a small round cell sarcoma presenting a translocation t(1;22)(p34;q12) [1].
 

High impact information on PATZ1

  • The zinc finger protein MAZR bound the Cd8 enhancer and interacted with the nuclear receptor corepressor N-CoR complex in double-negative thymocytes [2].
  • The association of PATZ with RNF4 switches the activation to repression of selected basal promoters [3].
  • Our findings demonstrate that PATZ is a novel AR coregulator that acts by modulating the effect of a coactivator [3].
  • Finally, we show that the repression of endogenous PATZ expression by antisense expression plasmids in LNCaP cells results in a stronger androgen response [3].
  • All the three breakpoints, two on 22q12 and one in 1p34, interrupt different genes: EWS, ZSG and UQCRH [1].
 

Biological context of PATZ1

  • The gene, designated ZSG (Zinc finger Sarcoma Gene), is a putative Cys2-His2 zinc finger protein which contains a POZ transcriptional repressor-like domain at the N-terminus [4].
  • On presentation of the Friedenwald Memorial Award in Ophthalmology to Arnall Patz [5].
  • ZSG was well described by a model based on Horsfield's asymmetric airway geometry at total lung capacity (TLC) with nonrigid walls [6].
  • Each year global warming and climate changes are affecting Mother Nature, causing extreme weather events to occur (Patz & Khaliq, 2002) [7].
 

Associations of PATZ1 with chemical compounds

  • Arnall Patz, MD: physician, scientist, and humanitarian: Director Emeritus, The Wilmer Eye Institute; recipient of the 2004 Presidential Medal of Freedom [8].

References

  1. UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines. Modena, P., Testi, M.A., Facchinetti, F., Mezzanzanica, D., Radice, M.T., Pilotti, S., Sozzi, G. Oncogene (2003) [Pubmed]
  2. Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B., Ellmeier, W. Nat. Immunol. (2006) [Pubmed]
  3. PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. Pero, R., Lembo, F., Palmieri, E.A., Vitiello, C., Fedele, M., Fusco, A., Bruni, C.B., Chiariotti, L. J. Biol. Chem. (2002) [Pubmed]
  4. A novel zinc finger gene is fused to EWS in small round cell tumor. Mastrangelo, T., Modena, P., Tornielli, S., Bullrich, F., Testi, M.A., Mezzelani, A., Radice, P., Azzarelli, A., Pilotti, S., Croce, C.M., Pierotti, M.A., Sozzi, G. Oncogene (2000) [Pubmed]
  5. On presentation of the Friedenwald Memorial Award in Ophthalmology to Arnall Patz. Silverstein, A.M. Invest. Ophthalmol. Vis. Sci. (1980) [Pubmed]
  6. Airway geometry and wall mechanical properties estimated from subglottal input impedance in humans. Habib, R.H., Chalker, R.B., Suki, B., Jackson, A.C. J. Appl. Physiol. (1994) [Pubmed]
  7. Mother Nature's Disasters and Their Health Effects: A Literature Review. Jones, J. Nursing forum. (2006) [Pubmed]
  8. Arnall Patz, MD: physician, scientist, and humanitarian: Director Emeritus, The Wilmer Eye Institute; recipient of the 2004 Presidential Medal of Freedom. Goldberg, M.F., McDonnell, P.J. Arch. Ophthalmol. (2005) [Pubmed]
 
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