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Gene Review:

Irak3 - interleukin-1 receptor-associated kinase 3

Mus musculus

Synonyms: 4833428C18Rik, AI563835, IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, ...

Pathak, S.K. et al., Li, H. et al., Taylor, A.W., Deng, J.C. et al., Kobayashi, K. et al.

Jane C. Deng, Genhong Cheng, Michael W. Newstead, Xianying Zeng, Koichi Kobayashi, Richard A. Flavell, Theodore J. Standiford, Taylor,

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Disease relevance of Irak3

TLR2 and TLR4 expression was unchanged in the lung following sepsis, whereas levels of IRAK-M were upregulated [1].

High impact information on Irak3

IRAK-M expression is restricted to monocytes/macrophages, whereas other IRAKs are ubiquitous [2].
Thus, IRAK-M acts as a dominant negative IRAK [3].
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation [3].
Knockdown of Irak-M expression by RNA interference reinstates LPS-induced IL-12 production in Man-LAM-pretreated cells [4].
The fact that Irak-M expression could be elicited by yeast mannan suggested that ligation of the mannose receptor by the mannooligosaccharide caps of LAM was the probable trigger for IRAK-M induction [4].

Regulatory relationships of Irak3

The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages [5].

References

Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. Deng, J.C., Cheng, G., Newstead, M.W., Zeng, X., Kobayashi, K., Flavell, R.A., Standiford, T.J. J. Clin. Invest. (2006) [Pubmed]
IRAK-M is a negative regulator of Toll-like receptor signaling. Kobayashi, K., Hernandez, L.D., Galán, J.E., Janeway, C.A., Medzhitov, R., Flavell, R.A. Cell (2002) [Pubmed]
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. Li, H., Cuartas, E., Cui, W., Choi, Y., Crawford, T.D., Ke, H.Z., Kobayashi, K.S., Flavell, R.A., Vignery, A. J. Exp. Med. (2005) [Pubmed]
Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. Pathak, S.K., Basu, S., Bhattacharyya, A., Pathak, S., Kundu, M., Basu, J. J. Biol. Chem. (2005) [Pubmed]
The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. Taylor, A.W. J. Neuroimmunol. (2005) [Pubmed]

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