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Gene Review:

WNT7B - wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-7b

Kirikoshi, H. et al., Kirikoshi, H. et al., van Bokhoven, H. et al.

van Bokhoven, Kissing, Schepens, van Beersum, Simons, Riegman, McMahon, McMahon, Brunner,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of WNT7B

In addition, WNT7B was up-regulated in 5 out of 10 cases of primary gastric cancer [1].
Expression levels of WNT7B mRNA in a lung cancer cell line A549, esophageal cancer cell lines TE2, TE3, TE4, TE5, TE6, TE7, TE10, TE12, a gastric cancer cell line TMK1, and pancreatic cancer cell lines BxPC-3, AsPC-1 and Hs766T were significantly higher than that in fetal kidney [1].

High impact information on WNT7B

Here, expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer were investigated [2].
Only partial coding sequence of human WNT7B is reported so far, and human genome draft sequence corresponding to the WNT7B gene in human chromosome 22q13 region is not available at present [1].
WNT7B encoded a 349-amino-acid polypeptide with three N-linked glycosylation sites and consensus amino-acid residues conserved among members of the WNT family [1].

Associations of WNT7B with chemical compounds

WNT7B, but not WNT7A, was slightly up-regulated by all-trans retinoic acid in NT2 cells [2].

Analytical, diagnostic and therapeutic context of WNT7B

Molecular cloning and characterization of human WNT7B [1].
Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization [3].

References

Molecular cloning and characterization of human WNT7B. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Kirikoshi, H., Katoh, M. Int. J. Oncol. (2002) [Pubmed]
Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization. van Bokhoven, H., Kissing, J., Schepens, M., van Beersum, S., Simons, A., Riegman, P., McMahon, J.A., McMahon, A.P., Brunner, H.G. Cytogenet. Cell Genet. (1997) [Pubmed]

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AgaP_AGAP010283	Anopheles gambiae str. PEST
WNT7B	Canis lupus familiaris
wnt7bb	Danio rerio
Wnt2	Drosophila melanogaster
WNT7B	Gallus gallus
WNT7B	Macaca mulatta
Wnt7b	Mus musculus
LOC465393	Pan troglodytes
Wnt7b	Rattus norvegicus

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