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Gene Review

Wnt7b  -  wingless-type MMTV integration site family...

Mus musculus

Synonyms: Protein Wnt-7b, Wnt-7b
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Disease relevance of Wnt7b

  • The level of expression of Wnt2 and Wnt4 was 10- to 20-fold higher in fibroadenomas than it was in normal or malignant breast tissue, and in 10% of tumors Wnt7b expression was 30-fold higher than in normal or benign breast tissues [1].
  • Mice lacking Wnt7b gene die soon after birth because of respiratory failure and display severe lung hypoplasia [2].
  • By using a murine retrovirus to ectopically express Wnt-7b in presumptive dental ectoderm in mandibular arch explants, we show that Shh expression in the ectoderm and Ptc expression in the underlying ectomesenchyme are down-regulated, and tooth development is subsequently arrested [3].

High impact information on Wnt7b

  • Although exogenous overexpression of Dkk before the expression of endogenous canonical Wnt (Wnt7b) suppressed osteogenesis in cultures, its expression after peak Wnt7b expression induced a phenotype resembling terminal osteoblast differentiation leading to mineralization [4].
  • In contrast, Wnt7b and Dvl activate Rac and JNK in hippocampal neurons [5].
  • Here we show that Wnt7b, which is expressed in the mouse hippocampus, increases dendritic branching in cultured hippocampal neurons [5].
  • We describe a reciprocal relationship between the expression of Wnt-7b in presumptive oral ectoderm and Shh in presumptive dental ectoderm in mouse embryos that mark boundaries between these cells with different developmental fates [3].
  • Biochemical analysis demonstrates that Wnt7b can bind to Fzd1 and -10 on the cell surface and cooperatively activate canonical Wnt signaling with these receptors in the presence of LRP5 [6].

Biological context of Wnt7b


Anatomical context of Wnt7b


Associations of Wnt7b with chemical compounds


Other interactions of Wnt7b

  • Mapping of closely linked genes in an interspecific backcross panel allowed us to exclude two previous candidate genes, Ly6 and Wnt7b [16].
  • In 0.5% serum, growth of the Wnt-1, Wnt-6 and Wnt-7b containing cells appeared to be inhibited [17].
  • Our results are also the first report of biological effects of Wnt-6 and Wnt-7b [17].
  • Whereas Wnt10b deficiency contributed to increased adipogenic potential in myoblasts, the augmented myogenic differentiation potential observed is likely the result of a compensatory increase in Wnt7b during differentiation of Wnt10b-/- myoblasts [18].
  • Furthermore, we found that expression of Wnt-7b, which overlapped with Pax-6 in the ventrolateral domain of the neural tube, was also specifically missing in the mutant hindbrain, while it remained intact in the dorsal non-overlapping domain [19].

Analytical, diagnostic and therapeutic context of Wnt7b


  1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet, E.L., McMahon, J.A., McMahon, A.P., Bicknell, R., Harris, A.L. Cancer Res. (1994) [Pubmed]
  2. Down-regulation of Wnt signal pathway in nitrofen-induced hypoplastic lung. Takayasu, H., Nakazawa, N., Montedonico, S., Puri, P. J. Pediatr. Surg. (2007) [Pubmed]
  3. Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Sarkar, L., Cobourne, M., Naylor, S., Smalley, M., Dale, T., Sharpe, P.T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Li, X., Liu, P., Liu, W., Maye, P., Zhang, J., Zhang, Y., Hurley, M., Guo, C., Boskey, A., Sun, L., Harris, S.E., Rowe, D.W., Ke, H.Z., Wu, D. Nat. Genet. (2005) [Pubmed]
  5. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Rosso, S.B., Sussman, D., Wynshaw-Boris, A., Salinas, P.C. Nat. Neurosci. (2005) [Pubmed]
  6. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Wang, Z., Shu, W., Lu, M.M., Morrisey, E.E. Mol. Cell. Biol. (2005) [Pubmed]
  7. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Hu, H., Hilton, M.J., Tu, X., Yu, K., Ornitz, D.M., Long, F. Development (2005) [Pubmed]
  8. Gli3 is required for the specification and differentiation of preplate neurons. Theil, T. Dev. Biol. (2005) [Pubmed]
  9. Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development. Kuemerle, B., Zanjani, H., Joyner, A., Herrup, K. J. Neurosci. (1997) [Pubmed]
  10. Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometrium and endometrial carcinoma. Bui, T.D., Zhang, L., Rees, M.C., Bicknell, R., Harris, A.L. Br. J. Cancer (1997) [Pubmed]
  11. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Parr, B.A., Shea, M.J., Vassileva, G., McMahon, A.P. Development (1993) [Pubmed]
  12. Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Shu, W., Jiang, Y.Q., Lu, M.M., Morrisey, E.E. Development (2002) [Pubmed]
  13. Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Patterson, L.T., Pembaur, M., Potter, S.S. Development (2001) [Pubmed]
  14. Wnt7b regulates placental development in mice. Parr, B.A., Cornish, V.A., Cybulsky, M.I., McMahon, A.P. Dev. Biol. (2001) [Pubmed]
  15. Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties. Burrus, L.W., McMahon, A.P. Exp. Cell Res. (1995) [Pubmed]
  16. Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15. Super, H.J., Hasenkrug, K.J., Simmons, S., Brooks, D.M., Konzek, R., Sarge, K.D., Morimoto, R.I., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Frankel, W., Chesebro, B. J. Virol. (1999) [Pubmed]
  17. Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family. Bradbury, J.M., Niemeyer, C.C., Dale, T.C., Edwards, P.A. Oncogene (1994) [Pubmed]
  18. Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Vertino, A.M., Taylor-Jones, J.M., Longo, K.A., Bearden, E.D., Lane, T.F., McGehee, R.E., MacDougald, O.A., Peterson, C.A. Mol. Biol. Cell (2005) [Pubmed]
  19. Pax-6 is involved in the specification of hindbrain motor neuron subtype. Osumi, N., Hirota, A., Ohuchi, H., Nakafuku, M., Iimura, T., Kuratani, S., Fujiwara, M., Noji, S., Eto, K. Development (1997) [Pubmed]
  20. Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium. Naylor, S., Smalley, M.J., Robertson, D., Gusterson, B.A., Edwards, P.A., Dale, T.C. J. Cell. Sci. (2000) [Pubmed]
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