Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ZFP37 - ZFP37 zinc finger protein

Homo sapiens

Synonyms: ZNF906, Zfp-37, Zinc finger protein 37 homolog, zfp-37

Payen, E. et al., Dreyer, S.D. et al.

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Disease relevance of ZFP37

The map location and expression pattern suggest ZFP-37 as a candidate gene for a craniofacial-limb malformation, Nager syndrome (acrofacial dysostosis) [1].

High impact information on ZFP37

Murine ZFP-37 is a member of the large family of C2H2 type zinc finger proteins [2].
Here we show that at the protein level ZFP-37 is detected readily in neurons of the adult central nervous system but hardly in testis [2].
During development Zfp-37 mRNA is most abundant in the developing central nervous system, and in the adult mouse expression is restricted largely to testis and brain [2].
Gene mapping with a somatic cell hybrid panel and fluorescence in situ hybridization (FISH) localized ZFP-37 to human Chr 9q32 [1].

References

Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. Dreyer, S.D., Zhou, L., Machado, M.A., Horton, W.A., Zabel, B., Winterpacht, A., Lee, B. Mamm. Genome (1998) [Pubmed]
The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. Payen, E., Verkerk, T., Michalovich, D., Dreyer, S.D., Winterpacht, A., Lee, B., De Zeeuw, C.I., Grosveld, F., Galjart, N. J. Biol. Chem. (1998) [Pubmed]

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