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Gene Review:

ZNF32 - zinc finger protein 32

Homo sapiens

Synonyms: C2H2-546, KOX30, Zinc finger protein 32, Zinc finger protein KOX30

Drew, P.D. et al., Cannizzaro, L.A. et al., Bray, P. et al.

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Disease relevance of ZNF32

Human zinc finger gene ZNF32 maps to a chromosome region on 10q23-24 in which deletions have been observed associated with malignant lymphoma on 10q22-23 and with carcinoma of the prostate on 10q24 [1].
Thus, C2H2-546 is a candidate regulatory molecule important in the formation of these tumors, and may serve as an important marker to distinguish HTLV-1 infected ATL versus HAM-TSP T cell lineages [2].

High impact information on ZNF32

Further, the genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (Kox1-Kox30) isolated from a human T-cell cDNA library [3].
C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells [2].
The C2H2-546 gene is conserved in humans and primates and maps to chromosome 10q11.2, a site associated with a variety of cancers [2].

References

Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. Cannizzaro, L.A., Aronson, M.M., Thiesen, H.J. Hum. Genet. (1993) [Pubmed]
C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells. Drew, P.D., Gado, A.M., Canning, R.D., Nagle, J.W., Dehejia, A.M., Polymeropoulos, M.H., Biddison, W.E., Jacobson, S., Becker, K.G. J. Neurovirol. (1997) [Pubmed]
Characterization and mapping of human genes encoding zinc finger proteins. Bray, P., Lichter, P., Thiesen, H.J., Ward, D.C., Dawid, I.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]

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