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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF140  -  zinc finger protein 140

Homo sapiens

Synonyms: Zinc finger protein 140, pHZ-39
 
 
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High impact information on ZNF140

  • A group of 21 genes was underexpressed (>5-fold) in affected vs unaffected family members, and among these were transcription factors and genes involved in myeloid differentiation, such as ZNF140 and myeloid nuclear differentiation antigen (MNDA) [1].
  • When the ZNF140 and ZNF91 were transfected with reporter plasmid, both showed repressor activity with additive effects [2].
  • Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors [2].
  • ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box [3].

References

  1. Differentially expressed genes in adult familial myelodysplastic syndromes. Pradhan, A., Mijovic, A., Mills, K., Cumber, P., Westwood, N., Mufti, G.J., Rassool, F.V. Leukemia (2004) [Pubmed]
  2. Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors. Nishimura, T., Narita, T., Miyazaki, E., Ito, T., Nishimoto, N., Yoshizaki, K., Martial, J.A., Bellfroid, E.J., Vissing, H., Taniyama, T. Int. Immunol. (2001) [Pubmed]
  3. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. Vissing, H., Meyer, W.K., Aagaard, L., Tommerup, N., Thiesen, H.J. FEBS Lett. (1995) [Pubmed]
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