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Gene Review:

ZNF91 - zinc finger protein 91

Homo sapiens

Synonyms: HPF7, HTF10, Zinc finger protein 91, Zinc finger protein HPF7, Zinc finger protein HTF10

Bellefroid, E.J. et al., Nishimura, T. et al., Hamilton, A.T. et al., Ogawa, T. et al., Bellefroid, E.J. et al., et al.

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Disease relevance of ZNF91

Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas [1].

High impact information on ZNF91

Three mRNA isoforms with sequence identity to ZNF91 were isolated by the polymerase chain reaction [2].
1. These ZNF91-related genes probably arose late during evolution since no homologous genes are detected in the mouse and rat genomes [2].
Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea [3].
In each species containing the ZNF91 family, the genes were clustered at one major site, on the chromosome(s) syntenic to human chromosome 19 [3].
These observations suggest that the ZNF91 gene cluster is a derived character specific to Anthropoidea, resulting from a duplication and amplification event some 55 million years ago in the common ancestor of simians [3].

Biological context of ZNF91

By using GGGAGGAGC and AATTTGTTTGCC as bait sequences, we cloned two zinc-finger proteins (ZNF140 and ZNF91) that bind to the F2-3 and F4-3 regions within the promoter of the human Fc gamma RIIB gene respectively [4].
When the ZNF140 and ZNF91 were transfected with reporter plasmid, both showed repressor activity with additive effects [4].
The tissue-specific expression patterns and rapid structural divergence of ZNF91 subfamily genes suggest a role in determining gene expression differences between species and the evolution of novel primate traits [5].
One particular subfamily of KRAB-ZNF genes, including ZNF91, has expanded specifically in primates to comprise more than 110 loci in the human genome [5].
One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Krüppel-associated box) ZF gene family and also the same chromosomal assignment [1].

Other interactions of ZNF91

Thus, these results indicate that these cloned ZNF140 and ZNF91 proteins function as repressors for the human Fc gamma RIIB transcription [4].
The HKr19 protein is a member of the large ZNF91 subfamily of KRAB zinc finger genes [6].

References

Enhanced expression in seminoma of human zinc finger genes located on chromosome 19. Ogawa, T., Poncelet, D.A., Kinoshita, Y., Noce, T., Takeda, M., Kawamoto, K., Udagawa, K., Lecocq, P.J., Marine, J.C., Martial, J.A., Hosaka, M. Cancer Genet. Cytogenet. (1998) [Pubmed]
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid, E.J., Marine, J.C., Ried, T., Lecocq, P.J., Rivière, M., Amemiya, C., Poncelet, D.A., Coulie, P.G., de Jong, P., Szpirer, C. EMBO J. (1993) [Pubmed]
Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid, E.J., Marine, J.C., Matera, A.G., Bourguignon, C., Desai, T., Healy, K.C., Bray-Ward, P., Martial, J.A., Ihle, J.N., Ward, D.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors. Nishimura, T., Narita, T., Miyazaki, E., Ito, T., Nishimoto, N., Yoshizaki, K., Martial, J.A., Bellfroid, E.J., Vissing, H., Taniyama, T. Int. Immunol. (2001) [Pubmed]
Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Hamilton, A.T., Huntley, S., Tran-Gyamfi, M., Baggott, D.M., Gordon, L., Stubbs, L. Genome Res. (2006) [Pubmed]
Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. Mark, C., Looman, C., Abrink, M., Hellman, L. DNA Cell Biol. (2001) [Pubmed]

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