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Gene Review

MNDA  -  myeloid cell nuclear differentiation antigen

Homo sapiens

Synonyms: Myeloid cell nuclear differentiation antigen, PYHIN3
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Disease relevance of MNDA


High impact information on MNDA


Biological context of MNDA


Anatomical context of MNDA

  • Therefore, IFI 16 and MNDA are members of a novel family of human DNA-binding proteins whose expression is associated with myeloid cell differentiation induced by cytokines and chemical agents [10].
  • Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis [2].
  • The effect of interferon alpha on the MNDA mRNA is also observed in the cell lines HL-60, U937, and THP-1 [1].
  • The expression and the primary structure of the MNDA indicates that it plays a role in the granulocyte/monocyte cell-specific response to interferon [7].
  • MNDA (human myeloid nuclear differentiation antigen) is expressed in specific lineages of hematopoietic cells and most notably at high levels in macrophages at sites of inflammation [2].

Associations of MNDA with chemical compounds


Physical interactions of MNDA

  • Nuclear IFI 16 was able to bind double-stranded DNA in vitro and exhibited a similar elution profile from DNA-cellulose as previously observed for MNDA and 204 [10].
  • MNDA participated in a ternary complex with YY1 and the YY1 target DNA element [8].
  • However, MNDA did bind the NPM-MLF1 product of the t(3;5) that contains the N-terminal 175 residues of NPM [13].
  • Microsequence analysis showed that MNDA bound the 100 kDa nucleolin protein [14].

Regulatory relationships of MNDA


Other interactions of MNDA

  • The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression [16].
  • One family is encoded by several structurally related genes located on murine chromosome 1 (Ifi 200 cluster) and three homologous genes (MNDA, IFI 16 and AIM2) located on human chromosome 1 as well, within a linkage group highly conserved between mouse and human [17].
  • A group of 21 genes was underexpressed (>5-fold) in affected vs unaffected family members, and among these were transcription factors and genes involved in myeloid differentiation, such as ZNF140 and myeloid nuclear differentiation antigen (MNDA) [18].
  • The MNDA-YY1 interaction enhanced the affinity of YY1 for its target DNA and decreased its rate of dissociation [8].
  • MNDA positive cells double labeled for CD68 in all tissue examined [2].

Analytical, diagnostic and therapeutic context of MNDA


  1. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. Briggs, R., Dworkin, L., Briggs, J., Dessypris, E., Stein, J., Stein, G., Lian, J. J. Cell. Biochem. (1994) [Pubmed]
  2. Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis. Briggs, R.C., Atkinson, J.B., Miranda, R.N. J. Cell. Biochem. (2005) [Pubmed]
  3. Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins. Burrus, G.R., Briggs, J.A., Briggs, R.C. J. Cell. Biochem. (1992) [Pubmed]
  4. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. Briggs, R.C., Shults, K.E., Flye, L.A., McClintock-Treep, S.A., Jagasia, M.H., Goodman, S.A., Boulos, F.I., Jacobberger, J.W., Stelzer, G.T., Head, D.R. Cancer Res. (2006) [Pubmed]
  5. Immunocytochemical analysis of MNDA in tissue sections and sorted normal bone marrow cells documents expression only in maturing normal and neoplastic myelomonocytic cells and a subset of normal and neoplastic B lymphocytes. Miranda, R.N., Briggs, R.C., Shults, K., Kinney, M.C., Jensen, R.A., Cousar, J.B. Hum. Pathol. (1999) [Pubmed]
  6. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. Briggs, R.C., Briggs, J.A., Ozer, J., Sealy, L., Dworkin, L.L., Kingsmore, S.F., Seldin, M.F., Kaur, G.P., Athwal, R.S., Dessypris, E.N. Blood (1994) [Pubmed]
  7. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. Briggs, J.A., Burrus, G.R., Stickney, B.D., Briggs, R.C. J. Cell. Biochem. (1992) [Pubmed]
  8. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. Xie, J., Briggs, J.A., Briggs, R.C. J. Cell. Biochem. (1998) [Pubmed]
  9. Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression. Doggett, K.L., Briggs, J.A., Linton, M.F., Fazio, S., Head, D.R., Xie, J., Hashimoto, Y., Laborda, J., Briggs, R.C. J. Cell. Biochem. (2002) [Pubmed]
  10. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. Dawson, M.J., Trapani, J.A. J. Cell. Biochem. (1995) [Pubmed]
  11. cis-diamminedichloroplatinum(II) cross-linking of the human myeloid cell nuclear differentiation antigen to DNA in HL-60 cells following 1,25-dihydroxy vitamin D3-induced monocyte differentiation. Gaczynski, M., Briggs, J.A., Wedrychowski, A., Olinski, R., Uskokovic, M., Lian, J.B., Stein, G.S., Briggs, R.C. Cancer Res. (1990) [Pubmed]
  12. Production and use of rat monoclonal antibodies to the human myeloid cell nuclear differentiation antigen. Hudson, C.R., Bellew, T., Briggs, J.A., Casey, S.B., Briggs, R.C. Hybridoma (1988) [Pubmed]
  13. MNDA binds NPM/B23 and the NPM-MLF1 chimera generated by the t(3;5) associated with myelodysplastic syndrome and acute myeloid leukemia. Xie, J., Briggs, J.A., Morris, S.W., Olson, M.O., Kinney, M.C., Briggs, R.C. Exp. Hematol. (1997) [Pubmed]
  14. Human myeloid cell nuclear differentiation antigen binds specifically to nucleolin. Xie, J., Briggs, J.A., Olson, M.O., Sipos, K., Briggs, R.C. J. Cell. Biochem. (1995) [Pubmed]
  15. Regulation and specificity of MNDA expression in monocytes, macrophages, and leukemia/B lymphoma cell lines. Briggs, R.C., Kao, W.Y., Dworkin, L.L., Briggs, J.A., Dessypris, E.N., Clark, J. J. Cell. Biochem. (1994) [Pubmed]
  16. The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. Dawson, M.J., Trapani, J.A., Briggs, R.C., Nicholl, J.K., Sutherland, G.R., Baker, E. Immunogenetics (1995) [Pubmed]
  17. The Ifi 200 genes: an emerging family of IFN-inducible genes. Landolfo, S., Gariglio, M., Gribaudo, G., Lembo, D. Biochimie (1998) [Pubmed]
  18. Differentially expressed genes in adult familial myelodysplastic syndromes. Pradhan, A., Mijovic, A., Mills, K., Cumber, P., Westwood, N., Mufti, G.J., Rassool, F.V. Leukemia (2004) [Pubmed]
  19. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha. Fukushi, M., Higuchi, M., Oie, M., Tetsuka, T., Kasolo, F., Ichiyama, K., Yamamoto, N., Katano, H., Sata, T., Fujii, M. Virus Genes (2003) [Pubmed]
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