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Gene Review:

UV24 - Ultraviolet damage, repair of, in UV24

Homo sapiens

This record was discontinued.

Vrieling, H. et al., Thompson, L.H. et al., Hall, H. et al., Andersson, B.S. et al., Balajee, A.S. et al.

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High impact information on UV24

We have amplified, cloned and sequenced the ERCC3 genes from wild type and 27-1, UV24 and MMC-2 CHO mutant cell lines and identified the sites of the respective mutations [1].
UV24 cell line has two mutations [1].
In UV5 (human XP-D homolog) and UV 24 (human XP-B homolog) cells, which are totally deficient in NER, the PCNA complex was not detectable at 30 min after UV [2].
RESULTS: The rank ordering of sensitivity to both 4HC and PM, based on the combined survival data, was UV41/UV4/UV20 > > UV61/UV24/UV135/EM9 > or = UV5 approximately AA8 [3].
The molecular nature of 254 nm ultraviolet light (UV)-induced mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in UV24 Chinese hamster ovary (CHO) cells, which are defective in nucleotide excision repair, was determined [4].

Biological context of UV24

The CHO UV-sensitive mutants UV24 and UV135 (complementation groups 3 and 5, respectively) are defective in nucleotide excision repair [5].
Chromosome 2 corrected UV24, and the gene responsible was designated ERCC3 [5].

References

Characterization of ERCC3 mutations in the Chinese hamster ovary 27-1, UV24 and MMC-2 cell lines. Hall, H., Gurský, J., Nicodemou, A., Rybanská, I., Kimlícková, E., Pirsel, M. Mutat. Res. (2006) [Pubmed]
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair. Balajee, A.S., May, A., Dianova, I., Bohr, V.A. Mutat. Res. (1998) [Pubmed]
Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs. Andersson, B.S., Sadeghi, T., Siciliano, M.J., Legerski, R., Murray, D. Cancer Chemother. Pharmacol. (1996) [Pubmed]
UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand. Vrieling, H., Zhang, L.H., van Zeeland, A.A., Zdzienicka, M.Z. Mutat. Res. (1992) [Pubmed]
Identification of nucleotide-excision-repair genes on human chromosomes 2 and 13 by functional complementation in hamster-human hybrids. Thompson, L.H., Carrano, A.V., Sato, K., Salazar, E.P., White, B.F., Stewart, S.A., Minkler, J.L., Siciliano, M.J. Somat. Cell Mol. Genet. (1987) [Pubmed]

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