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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mrs2  -  MRS2 magnesium transporter

Rattus norvegicus

Synonyms: MRS2-like protein, Magnesium transporter MRS2 homolog, mitochondrial, Mrs2l, Rpt
 
 
 
 
 
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High impact information on Mrs2l

  • Treatment of T. brucei cells with a chemical cross-linker resulted in co-immunoprecipitation of 20 S proteasome with all the Rpt and Rpn proteins that sedimented in a glycerol gradient to the position of 26 S proteasome [1].
  • RNA interference to block selectively the expression of proteasome 20 S core and Rpt subunits resulted in significant accumulation of ubiquitinated proteins accompanied by cessation of cell growth [1].
 

Analytical, diagnostic and therapeutic context of Mrs2l

  • Immunoblots showed the presence in T. brucei lysate of the Rpt proteins, which co-fractionated with the yeast 19 S proteasome complex by gel filtration and localized in the 19 S fraction of a glycerol gradient [1].

References

  1. An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei. Li, Z., Zou, C.B., Yao, Y., Hoyt, M.A., McDonough, S., Mackey, Z.B., Coffino, P., Wang, C.C. J. Biol. Chem. (2002) [Pubmed]
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