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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MRS2  -  MRS2 magnesium transporter

Homo sapiens

Synonyms: HPT, MRS2-like protein, MRS2L, Magnesium transporter MRS2 homolog, mitochondrial
 
 
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High impact information on MRS2L

  • It is concluded that treatment with cimetidine in 1 degree HPT is followed by histopathologic alterations leading to increased size of the diseased parathyroids [1].
  • Recent evidence suggests that cimetidine given pre-operatively in primary hyperparathyroidism (1 degree HPT) might cause structural changes in parathyroid glands, while its suppressive effects on the disease are disputable [1].
  • Both markers of osteoblastic bone formation, alkaline phosphatase activity and osteocalcin concentration in serum, and one index of osteoclastic bone degradation, the urinary hydroxyproline/creatinine ratio (OH-P/Cr), were decreased in HP and increased in 1 degree HPT, whereas only OH-P/Cr was elevated in patients with PHP [2].
  • Eukaryotic homologs of CorA, although clearly functional as Mg2+ transporters, have minimal sequence homology and include the Mrs2p mitochondrial Mg2+ channel and the ALR proteins of fungi [3].
  • The polarographic determination of lead in presence of 3-hydroxypyridine-2-thiol (HPT) has been investigated [4].
 

Analytical, diagnostic and therapeutic context of MRS2L

  • To determine these possible changes we studied 38 patients with 1 degree HPT who underwent parathyroidectomy [1].

References

  1. The effect of cimetidine on parathyroid function and histopathology in primary hyperparathyroidism. Sotsiou, F.C., Singhellakis, P.N., Nikou, A.D., Pappas, A.D., Vambouka, C., Sklivagou, N.G., Ikkos, D.G. J. Pathol. (1987) [Pubmed]
  2. Biochemical markers of bone turnover, intact serum parathyroid horn and renal calcium excretion in patients with pseudohypoparathyroidism and hypoparathyroidism before and during vitamin D treatment. Kruse, K., Kracht, U., Wohlfart, K., Kruse, U. Eur. J. Pediatr. (1989) [Pubmed]
  3. Magnesium transporters: properties, regulation and structure. Maguire, M.E. Front. Biosci. (2006) [Pubmed]
  4. Polarographic determination of lead in drinking water samples of Western U.P. districts with 3-hydroxypyridine-2-thiol. Sindhu, R.S. International journal of environmental analytical chemistry. (1987) [Pubmed]
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