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Gene Review

Secisbp2  -  SECIS binding protein 2

Rattus norvegicus

Synonyms: SECIS-binding protein 2, Sbp2, Selenocysteine insertion sequence-binding protein 2
 
 
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Disease relevance of Secisbp2

 

High impact information on Secisbp2

  • SBP2 also interacts specifically with the minimally functional 3' UTR of another selenoprotein mRNA, deiodinase 1 [1].
  • A characterization of SBP2 biochemical properties reveals that SBP2 binding is sensitive to oxidation and the presence of heparin, rRNA, and poly(G) [1].
  • The selenocysteine insertion sequence (SECIS) contains two essential tandem sheared G.A pairs that bind SECIS-binding protein 2 (SBP2), which recruits a selenocysteine-specific elongation factor and Sec-tRNA(Sec) to the ribosome [2].
  • We propose a model in which SBP2 and L30 carry out different functions in the UGA recoding mechanism, with the SECIS acting as a molecular switch upon protein binding [2].
 

Other interactions of Secisbp2

 

Analytical, diagnostic and therapeutic context of Secisbp2

  • SBP2 activity elutes with a molecular mass of approximately 500 kDa during gel filtration chromatography, suggesting the existence of a large functional complex [1].

References

 
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