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Gene Review

SCRN3  -  secernin 3

Homo sapiens

Synonyms: FLJ23142, Secernin-3
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Disease relevance of SCRN3

  • Columns were inoculated with Shewanella putrefaciens strain CN-32 or Sulfurospirillum barnesii strain SES-3, organisms capable of As (V) and Fe (III) reduction, or Bacillus benzoevorans strain HT-1, an organism capable of As(V) but not Fe(III) reduction [1].
  • Physiologically and phylogenetically, strain OREX-4 was far-removed from strains MIT-13 and SES-3: strain OREX-4 grew on different electron donors and electron acceptors, and fell within the gram-positive group of the Bacteria, whereas MIT-13 and SES-3 fell together in the epsilon-subdivision of the Proteobacteria [2].

High impact information on SCRN3

  • One highly suggestive QTL was located on chromosomes15 (Ses3) with a LOD score 3.4 (P = 1.2 x 10(-4)) [3].
  • A newly discovered arsenate-reducing bacterium, strain OREX-4, differed significantly from strains MIT-13 and SES-3, the previously described arsenate-reducing isolates, which grew on nitrate but not on sulfate [2].

Analytical, diagnostic and therapeutic context of SCRN3

  • Comparative 16S rDNA sequence analysis revealed a tight cluster consisting of the validly described species Sulfurospirillum deleyianum and the strains SES-3 and CCUG 13942 as the closest relatives of strain F1F6 (level of sequence similarity, 91.7 to 92.4%) [4].


  1. Contrasting effects of dissimilatory iron (III) and arsenic (V) reduction on arsenic retention and transport. Kocar, B.D., Herbel, M.J., Tufano, K.J., Fendorf, S. Environ. Sci. Technol. (2006) [Pubmed]
  2. Dissimilatory arsenate and sulfate reduction in Desulfotomaculum auripigmentum sp. nov. Newman, D.K., Kennedy, E.K., Coates, J.D., Ahmann, D., Ellis, D.J., Lovley, D.R., Morel, F.M. Arch. Microbiol. (1997) [Pubmed]
  3. Identification of genetic loci controlling bacterial clearance in experimental Salmonella enteritidis infection: an unexpected role of Nramp1 (Slc11a1) in the persistence of infection in mice. Caron, J., Loredo-Osti, J.C., Laroche, L., Skamene, E., Morgan, K., Malo, D. Genes Immun. (2002) [Pubmed]
  4. Sulfurospirillum arcachonense sp. nov., a new microaerophilic sulfur-reducing bacterium. Finster, K., Liesack, W., Tindall, B.J. Int. J. Syst. Bacteriol. (1997) [Pubmed]
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