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Gene Review:

PPP1R3B - protein phosphatase 1, regulatory subunit 3B

Homo sapiens

Synonyms: FLJ14005, GL, Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL, PP1 subunit R4, PPP1R4, ...

Dunn, J.S. et al., Katoh, M. et al.

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Disease relevance of PPP1R3B

Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23 [1].

High impact information on PPP1R3B

The PPP1R3B gene is located on chromosome 8p23 in a region that has been linked with type 2 diabetes and maturity-onset diabetes of the young (MODY) [1].
The product of the PPP1R3B gene (G(L)) is the regulatory subunit of PP1 - a serine/threonine phosphatase involved in the modulation of glycogen synthesis in the liver and skeletal muscle [1].
CLDN23 gene, linked to MFHAS1 and PPP1R3B genes, was mapped to human chromosome 8p23 [2].

References

Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Dunn, J.S., Mlynarski, W.M., Pezzolesi, M.G., Borowiec, M., Powers, C., Krolewski, A.S., Doria, A. Ann. Hum. Genet. (2006) [Pubmed]
CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]

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