Disease relevance of ZFHX4

• This, together with the finding that Zfhx4 was expressed transiently in differentiating P19 embryonal carcinoma cells and C2C12 myoblasts, suggests that ZFHX4/Zfhx4 is involved in neural and muscle differentiation [1].

High impact information on ZFHX4

• The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers [2].
• ZFHX4 was mapped to human chromosome 8q13.3-q21.11 by fluorescence in situ hybridization using BAC clone RP11-48D4 as a probe [1].
• Human ZFHX4 is about 180 kb long, containing 12 exons that encodes a 3599-amino acid protein carrying four homeodomains and 22 zinc fingers [1].

Analytical, diagnostic and therapeutic context of ZFHX4

• RT-PCR analysis showed that ZFHX4 transcripts were expressed in adult human brain, liver and muscle [1].
• Here, we report molecular cloning of the human ZFHX4 cDNA and genomic organization of this gene [1].

References