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Gene Review

SCD5  -  stearoyl-CoA desaturase 5

Homo sapiens

Synonyms: ACOD4, Acyl-CoA-desaturase 4, FADS4, FLJ21032, HSCD5, ...
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Disease relevance of SCD5

  • A search was made for predictors of sudden cardiac death (SCD) among 197 men, age 40 to 79, who had multiphasic health checkups and experienced SCD 2 days to 5 1/2 years later (mean 18.1 months) [1].

High impact information on SCD5

  • Unlike wild-type mice, SCD1-deficient mice failed to elevate the hepatic triglyceride monounsaturated acid (MUFA)/saturated fatty acid (SFA) ratio despite induction of the SCD2 gene [2].
  • The pericentric inversion disrupts a gene (ACOD4) on chromosome 4q21 that codes for a novel acyl-CoA desaturase enzyme [3].
  • The 3.0 kb human ACOD4 cDNA spans approximately 170 kb and is composed of five exons of ACOD4 [3].
  • These data suggested that hSCD5 plays a role distinct from that of hSCD1 during development and in normal physiological conditions [4].
  • Additionally, hSCD2 transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 expression is developmentally regulated [5].

Biological context of SCD5

  • Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding [6].
  • A homologous region in the stearoyl-CoA desaturase gene 2 (SCD2) promoter also mediated PUFA-specific repression in transfection experiments [7].

Anatomical context of SCD5

  • Microsome fractions prepared from hSCD1 and hSCD5 transfected cells displayed similar delta 9 desaturase activity [4].

Analytical, diagnostic and therapeutic context of SCD5

  • In the present study, we show using isothermal titration calorimetry that Scd2 binds two molecules of active GTP-bound Cdc42 simultaneously, but independently of one another [6].


  1. Predictors of sudden cardiac death. Friedman, G.D., Klatsky, A.L., Siegelaub, A.B. Circulation (1975) [Pubmed]
  2. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Chu, K., Miyazaki, M., Man, W.C., Ntambi, J.M. Mol. Cell. Biol. (2006) [Pubmed]
  3. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. Beiraghi, S., Zhou, M., Talmadge, C.B., Went-Sumegi, N., Davis, J.R., Huang, D., Saal, H., Seemayer, T.A., Sumegi, J. Gene (2003) [Pubmed]
  4. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Wang, J., Yu, L., Schmidt, R.E., Su, C., Huang, X., Gould, K., Cao, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  5. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Zhang, S., Yang, Y., Shi, Y. Biochem. J. (2005) [Pubmed]
  6. Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding. Wheatley, E., Rittinger, K. Biochem. J. (2005) [Pubmed]
  7. Localization of a polyunsaturated fatty acid response region in stearoyl-CoA desaturase gene 1. Waters, K.M., Miller, C.W., Ntambi, J.M. Biochim. Biophys. Acta (1997) [Pubmed]
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