Disease relevance of FBXO11

• Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study [1].

High impact information on FBXO11

• We show that FBXO11 promotes the neddylation of p53 both in vitro and in vivo [2].
• We have identified a protein, FLJ12673 or FBXO11, that contains domains characteristically present in protein arginine methyltransferases (PRMTs) [3].
• FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues [3].
• The underlying VIT1 gene maps to chromosome 2p16 [4].
• 'VIT1', a novel gene associated with vitiligo [4].

Biological context of FBXO11

• DESIGN: A total of 13 SNPs were genotyped across the 98.7 kilobases of genomic DNA encompassing FBXO11 [1].
• Incorporating multiple SNPs in 2- and 3-locus SNP haplotypes, those haplotypes containing rs2134056 also exhibited evidence of association of FBXO11 and COME/ROM (P values ranging from .03 to .10) [1].
• RESULTS: The FBXO11 SNPs are contained in a single linkage disequilibrium haplotype block [1].

Other interactions of FBXO11

• The 3' portion of the VIT1 message is complementary to the 3' end of hMSH6 mRNA, enabling the formation of RNA-RNA hybrids, which may interfere with G/T mismatch repair function [4].
• We report the identification of FBXO11, a member of the F-box protein family and a component of the Skp1.Cullin1.F-box (SCF) complex, as a new p53-interacting protein [2].
• VIT-1: the second member of a new branch of the von Willebrand factor A domain superfamily [5].

References