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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Otitis


High impact information on Otitis

  • We conclude that in infants and children with otitis media with effusion, amoxicillin treatment increases to some extent the likelihood of resolution [6].
  • We studied the efficacy of adenoidectomy in 213 children who had received tympanostomy-tube placement because of persistent and/or recurrent otitis media and had again developed otitis media after tubal extrusion [7].
  • Quantitative nasopharyngeal cultures were particularly useful in predicting the presence of ampicillin-resistant Haemophilus influenzae and group A streptococci as causative agents in otitis media [8].
  • Thirty-one of 35 patients with resistant H influenzae otitis were treated with an erythromycin/sulfisoxazole combination with an impressive clinical response [1].
  • Cephalexin monohydrate suspension. Treatment of otitis media [9].

Chemical compound and disease context of Otitis

  • Currently, 8% of all cases of acute otitis media in the Washington, DC, area are due to H influenzae resistant to ampicillin [1].
  • LPS prepared by hot phenol water extraction of each of the strains contained 45% (pneumonia isolate) and 60% (otitis isolate) lipid (wt/wt), 49% and 50% carbohydrate (wt/wt), respectively, and less than 1%, 3-deoxy-manno octulosonic acid [10].
  • Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants [11].
  • All animals developed acute bacterial otitis media that persisted for up to 3 wk, whereas isogenic sialic acid-deficient mutants (disrupted sialyltransferase or CMP-acetylneuraminic acid synthetase genes) were profoundly attenuated [12].
  • Loracarbef is a new oral antimicrobial of the carbacephem class with in vitro activity against the common pathogens associated with skin infections, otitis media, sinusitis, bronchopulmonary infections, and urinary tract infections [13].

Biological context of Otitis


Anatomical context of Otitis


Gene context of Otitis


Analytical, diagnostic and therapeutic context of Otitis


  1. The increasing incidence of Ampicillin-resistant Haemophilus influenzae. A cause of otitis media. Schwartz, R., Rodriguez, W., Khan, W., Ross, S. JAMA (1978) [Pubmed]
  2. Inappropriate use of oral ciprofloxacin. Frieden, T.R., Mangi, R.J. JAMA (1990) [Pubmed]
  3. Cyclosporin A treatment of young children with newly-diagnosed type 1 (insulin-dependent) diabetes mellitus. London Diabetes Study Group. Jenner, M., Bradish, G., Stiller, C., Atkison, P. Diabetologia (1992) [Pubmed]
  4. Otitis media and eustachian tube dysfunction: connection to allergic rhinitis. Fireman, P. J. Allergy Clin. Immunol. (1997) [Pubmed]
  5. Effect of xylitol on growth of Streptococcus pneumoniae in the presence of fructose and sorbitol. Tapiainen, T., Kontiokari, T., Sammalkivi, L., Ikäheimo, I., Koskela, M., Uhari, M. Antimicrob. Agents Chemother. (2001) [Pubmed]
  6. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. Mandel, E.M., Rockette, H.E., Bluestone, C.D., Paradise, J.L., Nozza, R.J. N. Engl. J. Med. (1987) [Pubmed]
  7. Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement. Results of parallel randomized and nonrandomized trials. Paradise, J.L., Bluestone, C.D., Rogers, K.D., Taylor, F.H., Colborn, D.K., Bachman, R.Z., Bernard, B.S., Schwarzbach, R.H. JAMA (1990) [Pubmed]
  8. The nasopharyngeal culture in acute otitis media. A reappraisal of its usefulness. Schwartz, R., Rodriguez, W.J., Mann, R., Khan, W., Ross, S. JAMA (1979) [Pubmed]
  9. Cephalexin monohydrate suspension. Treatment of otitis media. McLinn, S.E., Daly, J.F., Jones, J.E. JAMA (1975) [Pubmed]
  10. Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins. Gnehm, H.E., Pelton, S.I., Gulati, S., Rice, P.A. J. Clin. Invest. (1985) [Pubmed]
  11. Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. Engelhard, D., Cohen, D., Strauss, N., Sacks, T.G., Jorczak-Sarni, L., Shapiro, M. Lancet (1989) [Pubmed]
  12. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Bouchet, V., Hood, D.W., Li, J., Brisson, J.R., Randle, G.A., Martin, A., Li, Z., Goldstein, R., Schweda, E.K., Pelton, S.I., Richards, J.C., Moxon, E.R. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  13. In vitro activity of loracarbef and effects of susceptibility test methods. Doern, G. Am. J. Med. (1992) [Pubmed]
  14. Transforming growth factor-beta-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK. Jono, H., Xu, H., Kai, H., Lim, D.J., Kim, Y.S., Feng, X.H., Li, J.D. J. Biol. Chem. (2003) [Pubmed]
  15. Pneumococcal conjugate vaccine primes for polysaccharide-inducible IgG2 antibody response in children with recurrent otitis media acuta. Breukels, M.A., Rijkers, G.T., Voorhorst-Ogink, M.M., Zegers, B.J., Sanders, L.A. J. Infect. Dis. (1999) [Pubmed]
  16. Pharmacokinetics of azithromycin in pediatric patients with acute otitis media. Nahata, M.C., Koranyi, K.I., Luke, D.R., Foulds, G. Antimicrob. Agents Chemother. (1995) [Pubmed]
  17. Cefetamet pivoxil vs cefaclor in the treatment of acute otitis media in children. Furman, S., Berkowicz, L., Dippenaar, J., Hellenberg, D.A., Montanus, M.S., Steinberg, A., Schall, R. Drugs (1994) [Pubmed]
  18. Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. Whelan, M.A., Hwan, W.H., Beausoleil, J., Hauck, W.W., McGeady, S.J. J. Clin. Immunol. (2006) [Pubmed]
  19. The role of antihistamines in otitis. Fireman, P. J. Allergy Clin. Immunol. (1990) [Pubmed]
  20. Eustachian tube obstruction (ETO) after histamine nasal provocation--a double-blind dose-response study. Skoner, D.P., Doyle, W.J., Fireman, P. J. Allergy Clin. Immunol. (1987) [Pubmed]
  21. Breakdown of the round window membrane permeability barrier evoked by streptolysin O: possible etiologic role in development of sensorineural hearing loss in acute otitis media. Engel, F., Blatz, R., Kellner, J., Palmer, M., Weller, U., Bhadki, S. Infect. Immun. (1995) [Pubmed]
  22. Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model. Sato, K., Quartey, M.K., Liebeler, C.L., Le, C.T., Giebink, G.S. Infect. Immun. (1996) [Pubmed]
  23. Detection of Pneumococcal Capsular polysaccharide antigens by latex agglutination, counterimmunoelectrophoresis, and radioimmunoassay in middle ear exudates in acute otitis media. Leinonen, M.K. J. Clin. Microbiol. (1980) [Pubmed]
  24. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. Wang, B., Lim, D.J., Han, J., Kim, Y.S., Basbaum, C.B., Li, J.D. J. Biol. Chem. (2002) [Pubmed]
  25. Expression of cytokine genes during pneumococcal and nontypeable Haemophilus influenzae acute otitis media in the rat. Melhus, A., Ryan, A.F. Infect. Immun. (2000) [Pubmed]
  26. Characterization of mucins in human middle ear and Eustachian tube. Lin, J., Tsuprun, V., Kawano, H., Paparella, M.M., Zhang, Z., Anway, R., Ho, S.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  27. Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. Gentile, D.A., Doyle, W.J., Zeevi, A., Howe-Adams, J., Kapadia, S., Trecki, J., Skoner, D.P. Hum. Immunol. (2003) [Pubmed]
  28. Interleukin-8 expression in otitis media. Maxwell, K.S., Fitzgerald, J.E., Burleson, J.A., Leonard, G., Carpenter, R., Kreutzer, D.L. Laryngoscope (1994) [Pubmed]
  29. Modification of otitis media following vaccination with the capsular polysaccharide of Streptococcus pneumoniae in chinchillas. Giebink, G.S., Schiffman, G., Petty, K., Quie, P.G. J. Infect. Dis. (1978) [Pubmed]
  30. Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against otitis media and lung infection by nontypeable Haemophilus influenzae. Bertot, G.M., Becker, P.D., Guzmán, C.A., Grinstein, S. J. Infect. Dis. (2004) [Pubmed]
  31. Ceftriaxone: an update of its use in the management of community-acquired and nosocomial infections. Lamb, H.M., Ormrod, D., Scott, L.J., Figgitt, D.P. Drugs (2002) [Pubmed]
  32. Malignant external otitis: early scintigraphic detection. Strashun, A.M., Nejatheim, M., Goldsmith, S.J. Radiology. (1984) [Pubmed]
  33. Characterization of adherence of nontypeable Haemophilus influenzae to human epithelial cells. van Schilfgaarde, M., van Ulsen, P., Eijk, P., Brand, M., Stam, M., Kouame, J., van Alphen, L., Dankert, J. Infect. Immun. (2000) [Pubmed]
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