High impact information on MTERFD3

• Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein [1].
• Furthermore, ectopic expression of mTERFL suppresses cell growth and arrests cells in the G1 stage demonstrated by MTT and flow cytometry analysis [1].
• Expression of the GFP-mTERFL fusion protein in HeLa cells localized it to the mitochondria [1].
• The mTERFL gene consists of three exons and encodes 385 amino acids with 52% sequence similarity to the human mitochondrial transcription termination factor (mTERF) [1].
• To identify novel serum-inhibitory factors and study their roles in cell cycle regulation, we performed mRNA differential display analysis of U251 cells in the presence or absence of serum and cloned a novel gene encoding the human mitochondrial transcription termination factor-like protein (mTERFL) [1].

Regulatory relationships of MTERFD3

• The expression of mTERFL is dramatically inhibited by the addition of serum in serum-starved cells while the mTERF is rather induced [1].

Analytical, diagnostic and therapeutic context of MTERFD3

• Northern blot analysis detected three mTERFL transcripts of 1.7, 3.2, and 3.5kb [1].

References