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Gene Review:

GKAP1 - G kinase anchoring protein 1

Homo sapiens

Synonyms: FKSG21, G kinase-anchoring protein 1, GKAP42, cGMP-dependent protein kinase-anchoring protein of 42 kDa

Yuasa, K. et al., Wu, H. et al.

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High impact information on GKAP1

In contrast, N-terminal sequences that precede the first PDZ domain in SAP97, facilitated GKAP binding via its association with the SH3 domain [1].
GKAP42 mRNA is specifically expressed in testis, where it is restricted to the spermatocytes and early round spermatids [2].
Immunocytochemical observations revealed that GKAP42 is localized to the Golgi complex and that cGK-Ialpha is co-localized to the Golgi complex when coexpressed with GKAP42 [2].
These findings suggest that GKAP42 functions as an anchoring protein for cGK-Ialpha and that cGK-Ialpha may participate in germ cell development through phosphorylation of Golgi-associated proteins such as GKAP42 [2].

References

Intramolecular interactions regulate SAP97 binding to GKAP. Wu, H., Reissner, C., Kuhlendahl, S., Coblentz, B., Reuver, S., Kindler, S., Gundelfinger, E.D., Garner, C.C. EMBO J. (2000) [Pubmed]
Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. Yuasa, K., Omori, K., Yanaka, N. J. Biol. Chem. (2000) [Pubmed]

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