High impact information on RNF39

• In the HZF-16.1 cDNA, the fourth zinc finger domain is a fusion product of domains four and nine of HZF-16.2 and could potentially give rise to a new DNA-binding specificity [1].
• One cDNA (i.e., HZF-16.2) has nine zinc finger domains, while alternative splicing of the message gives rise to a smaller product (i.e., HZF-16.1) that has four domains [1].
• LIRF is an immediate-early gene in hippocampal granule cells, and its expression is upregulated immediately after the induction of long-lasting long-term potentiation at perforant pathway-dentate gyrus synapses and returns to the basal level within 150 min [2].
• LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein [2].
• The amino acid sequences of the mouse, rat, and human LIRF proteins are highly conserved and contain a putative PEST sequence [2].

Biological context of RNF39

• By extensive nucleotide sequence and Northern blot analysis, these cDNA clones were found to originate from approximately 42 different genes (HZF 1-42) of which only 8 have previously been described [3].

Anatomical context of RNF39

• A heterologously expressed LIRF protein fused to EGFP localizes specifically to the cytoplasm in COS-7 cells [2].

References