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Gene Review

CYTB  -  cytochrome b

Canis lupus familiaris

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High impact information on CYTB

  • Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b [1].
  • Mitochondrial DNA sequencing showed a G to A transition at 14,474 nt (G14474A, GenBank accession no. NC002008 ) that results in an amino acid change of valine-98 to methionine (V98M) of mitochondrial encoded cytochrome b [1].
  • Three of four regions of mtDNA, cytochrome b, cytochrome oxidase subunit II, and 16S rRNA genes were highly homogeneous among dog breeds, whereas the other region, the control region, showed relatively high polymorphisms with a maximum percentage difference of 3.18% [2].
  • Finally, we examined the phylogenetic relationships of wild dogs to other wolf-like canids through analysis of 736 base pairs (bp) of cytochrome b sequence and showed wild dogs to belong to a phylogenetically distinct lineage of the wolf-like canids [3].


  1. Canine spongiform leukoencephalomyelopathy is associated with a missense mutation in cytochrome b. Li, F.Y., Cuddon, P.A., Song, J., Wood, S.L., Patterson, J.S., Shelton, G.D., Duncan, I.D. Neurobiol. Dis. (2006) [Pubmed]
  2. Suitability of AFLP markers for the study of genetic relationships among Korean native dogs. Kim, K.S., Jeong, H.W., Park, C.K., Ha, J.H. Genes Genet. Syst. (2001) [Pubmed]
  3. Molecular genetic and morphological analyses of the African wild dog (Lycaon pictus). Girman, D.J., Kat, P.W., Mills, M.G., Ginsberg, J.R., Borner, M., Wilson, V., Fanshawe, J.H., Fitzgibbon, C., Lau, L.M., Wayne, R.K. J. Hered. (1993) [Pubmed]
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