Disease relevance of CYTB

• To evaluate the host-feeding patterns of Aedes vexans (Meigen) and Culiseta melanura (Coquillett) as secondary vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) in Northeastern United States, we identified the source of vertebrate bloodmeals by sequencing portions of the cytochrome b gene of mitochondrial DNA [1].

High impact information on CYTB

• Based on partial gene sequences from the cytochrome b, ND1 and ND5 genes, haplotype diversity was high but sequences were very closely related [2].
• Identification of mosquito bloodmeal source by terminal restriction fragment length polymorphism profile analysis of the cytochrome B gene [3].
• Anopheles sundaicus species A of the Southeast Asian A. sundaicus complex is formally named Anopheles epiroticus Linton & Harbach based on DNA sequence differentiation of the whole nuclear ITS2 region and a portion of both the cytochrome b and cytochrome c oxidase I mitochondrial genes [4].

Analytical, diagnostic and therapeutic context of CYTB

• PCR was performed on 123 blood or tissue samples from 55 avian, 13 mammalian, and one amphibian species by using end-labeled primers to amplify a 358-bp segment of cytb [3].
• Previous studies have shown that polymerase chain reaction (PCR) heteroduplex analysis (HDA) of the cytochrome B (cytb) gene is useful in identifying mosquito bloodmeals derived from avian hosts [3].

References