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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TTYH3  -  tweety family member 3

Homo sapiens

Synonyms: KIAA1691, Protein tweety homolog 3, hTTY3
 
 
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High impact information on TTYH3

  • Like a maxi-Cl(-) channel in situ, the hTTYH3 single channel showed 26-picosiemen linear current voltage, complex kinetics, 4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid sensitivity, subconductance, and the permeability order of I(-) > Br(-) > Cl(-) [1].
  • The whole cell current of hTTYH3 was large enough to be discriminated from the control but emerged only after treatment with ionomycin [1].
  • Expression of hTTYH3 in CHO cells generated a unique Cl- current activated by an increase in the intracellular Ca2+ concentration [2].

References

  1. A novel human Cl(-) channel family related to Drosophila flightless locus. Suzuki, M., Mizuno, A. J. Biol. Chem. (2004) [Pubmed]
  2. The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. Suzuki, M. Exp. Physiol. (2006) [Pubmed]
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