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Gene Review

Cblb  -  Casitas B-lineage lymphoma b

Mus musculus

Synonyms: AI429560, AI851073, Casitas B-lineage lymphoma proto-oncogene b, Cbl-b, E3 ubiquitin-protein ligase CBL-B, ...
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Disease relevance of Cblb


High impact information on Cblb

  • Furthermore, in the absence of a key negative regulatory molecule, Cbl-b, 100% of mice develop autoimmunity upon infection with viruses encoding the lower-affinity ligand [5].
  • The main TCR signalling pathways, such as tyrosine kinases Zap-70 and Lck, Ras/mitogen-activated kinases, phospholipase Cgamma-1 and Ca2+ mobilization, were not affected in Cbl-b(-/-) T cells [1].
  • Here we show that gene-targeted mice lacking the adaptor Cbl-b develop spontaneous autoimmunity characterized by auto-antibody production, infiltration of activated T and B lymphocytes into multiple organs, and parenchymal damage [6].
  • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [6].
  • Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction [7].

Biological context of Cblb


Anatomical context of Cblb


Associations of Cblb with chemical compounds


Regulatory relationships of Cblb


Other interactions of Cblb


Analytical, diagnostic and therapeutic context of Cblb


  1. Cbl-b regulates the CD28 dependence of T-cell activation. Chiang, Y.J., Kole, H.K., Brown, K., Naramura, M., Fukuhara, S., Hu, R.J., Jang, I.K., Gutkind, J.S., Shevach, E., Gu, H. Nature (2000) [Pubmed]
  2. Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation. Suzue, N., Nikawa, T., Onishi, Y., Yamada, C., Hirasaka, K., Ogawa, T., Furochi, H., Kosaka, H., Ishidoh, K., Gu, H., Takeda, S., Ishimaru, N., Hayashi, Y., Yamamoto, H., Kishi, K., Yasui, N. J. Bone Miner. Res. (2006) [Pubmed]
  3. Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus. Datta, S.K. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  4. E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Bachmaier, K., Toya, S., Gao, X., Triantafillou, T., Garrean, S., Park, G.Y., Frey, R.S., Vogel, S., Minshall, R., Christman, J.W., Tiruppathi, C., Malik, A.B. Nat. Med. (2007) [Pubmed]
  5. TCR affinity and negative regulation limit autoimmunity. Gronski, M.A., Boulter, J.M., Moskophidis, D., Nguyen, L.T., Holmberg, K., Elford, A.R., Deenick, E.K., Kim, H.O., Penninger, J.M., Odermatt, B., Gallimore, A., Gascoigne, N.R., Ohashi, P.S. Nat. Med. (2004) [Pubmed]
  6. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y.Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P.S., Sarosi, I., Nishina, H., Lipkowitz, S., Penninger, J.M. Nature (2000) [Pubmed]
  7. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Jeon, M.S., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., Bouchard, D., Jones, R., Gronski, M., Ohashi, P., Wada, T., Bloom, D., Fathman, C.G., Liu, Y.C., Penninger, J.M. Immunity (2004) [Pubmed]
  8. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. Liu, J., DeYoung, S.M., Hwang, J.B., O'Leary, E.E., Saltiel, A.R. J. Biol. Chem. (2003) [Pubmed]
  9. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. Rao, N., Dodge, I., Band, H. J. Leukoc. Biol. (2002) [Pubmed]
  10. Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. Wohlfert, E.A., Callahan, M.K., Clark, R.B. J. Immunol. (2004) [Pubmed]
  11. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. Krawczyk, C.M., Jones, R.G., Atfield, A., Bachmaier, K., Arya, S., Odermatt, B., Ohashi, P.S., Penninger, J.M. J. Immunol. (2005) [Pubmed]
  12. Cbl-b differentially regulates activation-induced apoptosis in T helper 1 and T helper 2 cells. Hanlon, A., Jang, S., Salgame, P. Immunology (2005) [Pubmed]
  13. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Heissmeyer, V., Macián, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L., Rao, A. Nat. Immunol. (2004) [Pubmed]
  14. Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl). Zeng, S., Xu, Z., Lipkowitz, S., Longley, J.B. Blood (2005) [Pubmed]
  15. Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells. Gustin, S.E., Thien, C.B., Langdon, W.Y. J. Immunol. (2006) [Pubmed]
  16. Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor. Zhang, J., Chiang, Y.J., Hodes, R.J., Siraganian, R.P. J. Immunol. (2004) [Pubmed]
  17. Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk. Sohn, H.W., Gu, H., Pierce, S.K. J. Exp. Med. (2003) [Pubmed]
  18. Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. Yasuda, T., Tezuka, T., Maeda, A., Inazu, T., Yamanashi, Y., Gu, H., Kurosaki, T., Yamamoto, T. J. Exp. Med. (2002) [Pubmed]
  19. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. Szymkiewicz, I., Kowanetz, K., Soubeyran, P., Dinarina, A., Lipkowitz, S., Dikic, I. J. Biol. Chem. (2002) [Pubmed]
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