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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cxcr6  -  chemokine (C-X-C motif) receptor 6

Mus musculus

Synonyms: BB217514, BONZO, C-X-C chemokine receptor type 6, CXC-R6, CXCR-6, ...
 
 
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Disease relevance of Cxcr6

  • Although STRL33 remains an orphan receptor, we have shown that it can function as a co-receptor for HIV-1 envelope glycoproteins, and that it is active with a broader range of HIV-1 envelope glycoproteins than the major co-receptors described to date [1].
  • We used a direct transplant model to test the sensitivity of medulloblastoma arising in Cxcr6 mutant mice to a small-molecule inhibitor of Smoothened (HhAntag) [2].
 

High impact information on Cxcr6

References

  1. Chemokines, lymphocytes, and HIV. Farber, J.M. Braz. J. Med. Biol. Res. (1998) [Pubmed]
  2. Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Sasai, K., Romer, J.T., Kimura, H., Eberhart, D.E., Rice, D.S., Curran, T. Cancer Res. (2007) [Pubmed]
  3. The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. Hase, K., Murakami, T., Takatsu, H., Shimaoka, T., Iimura, M., Hamura, K., Kawano, K., Ohshima, S., Chihara, R., Itoh, K., Yonehara, S., Ohno, H. J. Immunol. (2006) [Pubmed]
  4. Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system. Dong, H., Toyoda, N., Yoneyama, H., Kurachi, M., Kasahara, T., Kobayashi, Y., Inadera, H., Hashimoto, S., Matsushima, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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