Gene Review:
CXCR6 - chemokine (C-X-C motif) receptor 6
Homo sapiens
Synonyms:
BONZO, C-X-C chemokine receptor type 6, CD186, CDw186, CXC-R6, ...
Aust,
Kamprad,
Lamesch,
Schmücking,
Koprak,
Matheravidathu,
Springer,
Gould,
Dumont,
Murphy,
Wade-Evans,
Russell,
Jenkins,
Javan,
Blaak,
Boers,
Gruters,
Schuitemaker,
van der Ende,
Osterhaus,
Nanki,
Shimaoka,
Hayashida,
Taniguchi,
Yonehara,
Miyasaka,
Berahovich,
Lai,
Wei,
Lanier,
Schall,
Tscherning-Casper,
Vödrös,
Menu,
Aperia,
Fredriksson,
Dolcini,
Chaouat,
Barré-Sinoussi,
Albert,
Fenyö,
- CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia. Blaak, H., Boers, P.H., Gruters, R.A., Schuitemaker, H., van der Ende, M.E., Osterhaus, A.D. J. Virol. (2005)
- Coreceptor usage of HIV-1 isolates representing different genetic subtypes obtained from pregnant Cameroonian women. European Network for In Utero Transmission of HIV-1. Tscherning-Casper, C., Vödrös, D., Menu, E., Aperia, K., Fredriksson, R., Dolcini, G., Chaouat, G., Barré-Sinoussi, F., Albert, J., Fenyö, E.M. J. Acquir. Immune Defic. Syndr. (2000)
- The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells. Ignatius, R., Wei, Y., Beaulieu, S., Gettie, A., Steinman, R.M., Pope, M., Mojsov, S. AIDS Res. Hum. Retroviruses (2000)
- Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells. Ludwig, A., Schulte, A., Schnack, C., Hundhausen, C., Reiss, K., Brodway, N., Held-Feindt, J., Mentlein, R. J. Neurochem. (2005)
- In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Scarlatti, G., Tresoldi, E., Björndal, A., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyö, E.M., Lusso, P. Nat. Med. (1997)
- International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Murphy, P.M. Pharmacol. Rev. (2002)
- STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. Liao, F., Alkhatib, G., Peden, K.W., Sharma, G., Berger, E.A., Farber, J.M. J. Exp. Med. (1997)
- Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Langenkamp, A., Nagata, K., Murphy, K., Wu, L., Lanzavecchia, A., Sallusto, F. Eur. J. Immunol. (2003)
- Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. Koprak, S., Matheravidathu, S., Springer, M., Gould, S., Dumont, F.J. Cell. Immunol. (2003)
- Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. Wilbanks, A., Zondlo, S.C., Murphy, K., Mak, S., Soler, D., Langdon, P., Andrew, D.P., Wu, L., Briskin, M. J. Immunol. (2001)
- Broad spectrum of coreceptor usage and rapid disease progression in HIV-1-infected individuals from Central African Republic. Bégaud, E., Feindirongai, G., Versmisse, P., Ipero, J., Léal, J., Germani, Y., Morvan, J., Fleury, H., Müller-Trutwin, M., Barré-Sinoussi, F., Pancino, G. AIDS Res. Hum. Retroviruses (2003)
- Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells. Calabresi, P.A., Yun, S.H., Allie, R., Whartenby, K.A. J. Neuroimmunol. (2002)
- Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. Nakayama, T., Hieshima, K., Izawa, D., Tatsumi, Y., Kanamaru, A., Yoshie, O. J. Immunol. (2003)
- Evidence for NK cell subsets based on chemokine receptor expression. Berahovich, R.D., Lai, N.L., Wei, Z., Lanier, L.L., Schall, T.J. J. Immunol. (2006)
- Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4+ T cells. Tabata, S., Kadowaki, N., Kitawaki, T., Shimaoka, T., Yonehara, S., Yoshie, O., Uchiyama, T. J. Leukoc. Biol. (2005)
- TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells. Patel, D.N., Bailey, S.R., Gresham, J.K., Schuchman, D.B., Shelhamer, J.H., Goldstein, B.J., Foxwell, B.M., Stemerman, M.B., Maranchie, J.K., Valente, A.J., Mummidi, S., Chandrasekar, B. Biochem. Biophys. Res. Commun. (2006)
- Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry. Pöhlmann, S., Lee, B., Meister, S., Krumbiegel, M., Leslie, G., Doms, R.W., Kirchhoff, F. J. Virol. (2000)
- CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway. Ruth, J.H., Haas, C.S., Park, C.C., Amin, M.A., Martinez, R.J., Haines, G.K., Shahrara, S., Campbell, P.L., Koch, A.E. Arthritis Rheum. (2006)
- G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models. Unutmaz, D., KewalRamani, V.N., Littman, D.R. Semin. Immunol. (1998)
- HIV type 1 molecular clones able to use the Bonzo/STRL-33 coreceptor for virus entry. Zhang, Y.J., Zhang, L., Ketas, T., Korber, B.T., Moore, J.P. AIDS Res. Hum. Retroviruses (2001)
- Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Nanki, T., Shimaoka, T., Hayashida, K., Taniguchi, K., Yonehara, S., Miyasaka, N. Arthritis Rheum. (2005)
- Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease. Morgan, A.J., Guillen, C., Symon, F.A., Huynh, T.T., Berry, M.A., Entwisle, J.J., Briskin, M., Pavord, I.D., Wardlaw, A.J. Clin. Exp. Allergy (2005)
- CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves' disease (GD). Aust, G., Kamprad, M., Lamesch, P., Schmücking, E. Eur. J. Endocrinol. (2005)
- Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV. Wade-Evans, A.M., Russell, J., Jenkins, A., Javan, C. AIDS Res. Hum. Retroviruses (2001)