The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Il18bp  -  interleukin 18 binding protein

Mus musculus

Synonyms: IL-18BP, Igifbp, Interferon gamma-inducing factor-binding protein, Interleukin-18-binding protein, MC54L
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Il18bp


High impact information on Il18bp

  • Several Poxviruses encode putative proteins highly homologous to IL-18BP, suggesting that viral products may attenuate IL-18 and interfere with the cytotoxic T cell response [4].
  • By neutralizing IL-18 activity with IL-18 binding protein (IL-18BP), we observed that islets produce bioactive IL-18 [5].
  • In vivo, transgenic mice overproducing IL-18BP (IL-18BP-Tg) exhibited delayed hyperglycemia induced by beta cell toxic streptozotocin [5].
  • In testing whether IL-1F7b interacts with IL-18BP, we unexpectedly observed that IL-1F7b enhanced the ability of IL-18BP to inhibit IL-18-induced IFNgamma by 25-30% in a human natural killer cell line [6].
  • Molecular modeling identified a large mixed electrostatic and hydrophobic binding site in the Ig domain of IL-18BP, which could account for its high affinity binding to the ligand [7].

Biological context of Il18bp

  • More importantly, transfection with the IL-18BP plasmid induces profound changes in plaque composition (decrease in macrophage, T cell, cell death, and lipid content and increase in smooth muscle cell and collagen content) leading to a stable plaque phenotype [8].
  • The murine interleukin-18 binding protein cDNA was cloned after RT-PCR using mixed primer pair sequences based on partial murine interleukin-18 binding protein amino acid sequence analysis [9].
  • Using point mutagenesis, we analyzed the ectromelia virus IL-18BP to identify residues involved in binding [3].
  • Subsequently, human interleukin-18 binding protein cDNA was cloned from cDNA libraries of normal human liver using murine interleukin-18 binding protein cDNA as a probe [9].
  • Ischemia was produced by artery femoral occlusion in mice that were subjected to in vivo intramuscular electrotransfer of either an empty plasmid or a murine IL-18BP plasmid [10].

Anatomical context of Il18bp

  • Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb [10].
  • IL-18BP and TCR gamma delta cells appear to be critical factors in the anti-inflammatory effects of IRF-1 [11].
  • Twelve hours after IL-18BP, hepatic sinusoidal endothelium (HSE) cells were isolated, and adhesion of B16M cells to these cultured HSE cells was reduced to the level of vehicle-treated mice [12].

Associations of Il18bp with chemical compounds

  • Interleukin-18 binding protein is a novel glycoprotein that we successfully cloned and expressed [9].

Regulatory relationships of Il18bp


Other interactions of Il18bp


Analytical, diagnostic and therapeutic context of Il18bp

  • Angiographic score, capillary density (CD31 staining), and laser Doppler perfusion data at day 28 showed significant improvement in ischemic/nonischemic leg ratio by respectively 1.6-, 1.4-, and 1.5-fold in IL-18BP-treated mice compared with controls (P<0.01) [10].
  • Using this monoclonal antibody, we have developed an ELISA for determining IL-18BP levels [16].


  1. Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins. Smith, V.P., Bryant, N.A., Alcamí, A. J. Gen. Virol. (2000) [Pubmed]
  2. Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus. Xiang, Y., Moss, B. Virology (1999) [Pubmed]
  3. Identification of residues in an orthopoxvirus interleukin-18 binding protein involved in ligand binding and species specificity. Esteban, D.J., Buller, R.M. Virology (2004) [Pubmed]
  4. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Novick, D., Kim, S.H., Fantuzzi, G., Reznikov, L.L., Dinarello, C.A., Rubinstein, M. Immunity (1999) [Pubmed]
  5. Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor. Lewis, E.C., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Bufler, P., Azam, T., Gamboni-Robertson, F., Reznikov, L.L., Kumar, S., Dinarello, C.A., Kim, S.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Kim, S.H., Eisenstein, M., Reznikov, L., Fantuzzi, G., Novick, D., Rubinstein, M., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability. Mallat, Z., Corbaz, A., Scoazec, A., Graber, P., Alouani, S., Esposito, B., Humbert, Y., Chvatchko, Y., Tedgui, A. Circ. Res. (2001) [Pubmed]
  9. Cloning and expression of interleukin-18 binding protein. Aizawa, Y., Akita, K., Taniai, M., Torigoe, K., Mori, T., Nishida, Y., Ushio, S., Nukada, Y., Tanimoto, T., Ikegami, H., Ikeda, M., Kurimoto, M. FEBS Lett. (1999) [Pubmed]
  10. Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb. Mallat, Z., Silvestre, J.S., Le Ricousse-Roussanne, S., Lecomte-Raclet, L., Corbaz, A., Clergue, M., Duriez, M., Barateau, V., Akira, S., Tedgui, A., Tobelem, G., Chvatchko, Y., Lévy, B.I. Circ. Res. (2002) [Pubmed]
  11. Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein. Siegmund, B., Sennello, J.A., Lehr, H.A., Senaldi, G., Dinarello, C.A., Fantuzzi, G. Eur. J. Immunol. (2004) [Pubmed]
  12. Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium. Carrascal, M.T., Mendoza, L., Valcárcel, M., Salado, C., Egilegor, E., Tellería, N., Vidal-Vanaclocha, F., Dinarello, C.A. Cancer Res. (2003) [Pubmed]
  13. Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy. Remick, D.G., Bolgos, G.E., Siddiqui, J. Crit. Care Med. (2003) [Pubmed]
  14. IL-10 fails to inhibit the production of IL-18 in response to inflammatory stimuli. Zediak, V.P., Hunter, C.A. Cytokine (2003) [Pubmed]
  15. Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system. Dong, H., Toyoda, N., Yoneyama, H., Kurachi, M., Kasahara, T., Kobayashi, Y., Inadera, H., Hashimoto, S., Matsushima, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. A monoclonal antibody specific for rat IL-18BP and its application in determining serum IL-18BP. Maiti, P.K., Im, S.H., Souroujon, M.C., Fuchs, S. Immunol. Lett. (2003) [Pubmed]
WikiGenes - Universities