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Gene Review

Abcc6  -  ATP-binding cassette, subfamily C...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family C member 6, MLP-1, MRP-like protein 1, Mlp1, Mrp6, ...
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High impact information on Abcc6

  • Northern blot analysis indicated that MLP-1 is expressed predominantly in the liver in both SD rats and EHBR, whereas hepatic expression of MLP-2 was observed only in EHBR [1].
  • The expression of the basolateral transporter Mrp1 was not altered in pregnancy, whereas expression of Mrp6 mRNA was decreased by 60% [2].
  • CONCLUSIONS: These results demonstrate that MRPs or MRP-like transport system(s) may play an important role in fluorescein distribution across both BBB and BCSFB [3].
  • These results indicated that the transport of calcein and possibly other organic anions across the intestinal membrane may be regulated by the MRP-like protein, but not P-glycoprotein [4].

Analytical, diagnostic and therapeutic context of Abcc6

  • PURPOSE: The purpose of this study was to characterize the function of multidrug resistance-associated proteins (MRPs) (or MRP-like organic anion transport systems) in the blood-brain harrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB) using both an in vitro BBB model and an in vivo microdialysis model [3].


  1. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., Sugiyama, Y. Mol. Pharmacol. (1998) [Pubmed]
  2. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. Cao, J., Stieger, B., Meier, P.J., Vore, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  3. Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models. Sun, H., Miller, D.W., Elmquist, W.F. Pharm. Res. (2001) [Pubmed]
  4. Calcein is excreted from the intestinal mucosal cell membrane by the active transport system. Fujita, T., Yamada, H., Fukuzumi, M., Nishimaki, A., Yamamoto, A., Muranishi, S. Life Sci. (1997) [Pubmed]
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