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Gene Review

Abcc1  -  ATP-binding cassette, subfamily C...

Rattus norvegicus

Synonyms: ATP-binding cassette sub-family C member 1, Abcc1a, Avcc1a, LTC4 transporter, Leukotriene C(4) transporter, ...
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Disease relevance of Abcc1


High impact information on Abcc1


Biological context of Abcc1


Anatomical context of Abcc1


Associations of Abcc1 with chemical compounds


Regulatory relationships of Abcc1


Other interactions of Abcc1

  • Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells [14].
  • PURPOSE: To establish a method for isolating highly purified brain capillary endothelial cells (BCECs) from rat brain by using magnetic cell sorting, and clarify the expression levels of multidrug resistance-associated protein (Mrp) subtypes in these highly purified BCECs [18].
  • We conclude that induced expression of basolateral Mrp3 by EE may represent a compensatory mechanism to prevent intracellular accumulation of common Mrp substrates, either endogenous or exogenous, due to reduced expression and activity of apical Mrp2 [19].
  • Thus, acquired tolerance to arsenic is associated with increased expression GST-Pi, Mrp1/Mrp2 and P-glycoprotein, which function together to reduce cellular arsenic accumulation [20].
  • The expression of the basolateral transporter Mrp1 was not altered in pregnancy, whereas expression of Mrp6 mRNA was decreased by 60% [21].

Analytical, diagnostic and therapeutic context of Abcc1


  1. The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells. Payen, L., Courtois, A., Vernhet, L., Guillouzo, A., Fardel, O. Int. J. Cancer (1999) [Pubmed]
  2. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Miller, D.S., Nobmann, S.N., Gutmann, H., Toeroek, M., Drewe, J., Fricker, G. Mol. Pharmacol. (2000) [Pubmed]
  3. Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Soroka, C.J., Lee, J.M., Azzaroli, F., Boyer, J.L. Hepatology (2001) [Pubmed]
  4. The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. Keppler, D., Leier, I., Jedlitschky, G., Mayer, R., Büchler, M. Adv. Enzyme Regul. (1996) [Pubmed]
  5. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. Mayer, R., Kartenbeck, J., Büchler, M., Jedlitschky, G., Leier, I., Keppler, D. J. Cell Biol. (1995) [Pubmed]
  6. Bile acid transport across the hepatocyte canalicular membrane. Suchy, F.J., Sippel, C.J., Ananthanarayanan, M. FASEB J. (1997) [Pubmed]
  7. A unique multifunctional transporter translocates estradiol-17beta -glucuronide in rat liver microsomal vesicles. Battaglia, E., Gollan, J. J. Biol. Chem. (2001) [Pubmed]
  8. Small hepatocytes in culture develop polarized transporter expression and differentiation. Sidler Pfändler, M.A., Höchli, M., Inderbitzin, D., Meier, P.J., Stieger, B. J. Cell. Sci. (2004) [Pubmed]
  9. Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Ji, B., Ito, K., Sekine, S., Tajima, A., Horie, T. Free Radic. Biol. Med. (2004) [Pubmed]
  10. Shiga-like toxin II impairs hepatobiliary transport of doxorubicin in rats by down-regulation of hepatic P glycoprotein and multidrug resistance-associated protein Mrp2. Hidemura, K., Zhao, Y.L., Ito, K., Nakao, A., Tatsumi, Y., Kanazawa, H., Takagi, K., Ohta, M., Hasegawa, T. Antimicrob. Agents Chemother. (2003) [Pubmed]
  11. D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro. Legen, I., Kristl, A. Pharm. Res. (2004) [Pubmed]
  12. Metabolism and disposition of gemfibrozil in Wistar and multidrug resistance-associated protein 2-deficient TR- rats. Kim, M.S., Liu, D.Q., Strauss, J.R., Capodanno, I., Yao, Z., Fenyk-Melody, J.E., Franklin, R.B., Vincent, S.H. Xenobiotica (2003) [Pubmed]
  13. Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Kauffmann, H.M., Keppler, D., Kartenbeck, J., Schrenk, D. Hepatology (1997) [Pubmed]
  14. Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. Regina, A., Koman, A., Piciotti, M., El Hafny, B., Center, M.S., Bergmann, R., Couraud, P.O., Roux, F. J. Neurochem. (1998) [Pubmed]
  15. ATP binding cassette transporter gene expression in rat liver progenitor cells. Ros, J.E., Roskams, T.A., Geuken, M., Havinga, R., Splinter, P.L., Petersen, B.E., LaRusso, N.F., van der Kolk, D.M., Kuipers, F., Faber, K.N., Müller, M., Jansen, P.L. Gut (2003) [Pubmed]
  16. P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes. Mercier, C., Declèves, X., Masseguin, C., Fragner, P., Tardy, M., Roux, F., Gabrion, J., Scherrmann, J.M. J. Neurochem. (2003) [Pubmed]
  17. Characterization of inducible nature of MRP3 in rat liver. Ogawa, K., Suzuki, H., Hirohashi, T., Ishikawa, T., Meier, P.J., Hirose, K., Akizawa, T., Yoshioka, M., Sugiyama, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  18. Establishing a Method to Isolate Rat Brain Capillary Endothelial Cells by Magnetic Cell Sorting and Dominant mRNA Expression of Multidrug Resistance-associated Protein 1 and 4 in Highly Purified Rat Brain Capillary Endothelial Cells. Ohtsuki, S., Yamaguchi, H., Asashima, T., Terasaki, T. Pharm. Res. (2007) [Pubmed]
  19. Ethynylestradiol increases expression and activity of rat liver MRP3. Ruiz, M.L., Villanueva, S.S., Luquita, M.G., Vore, M., Mottino, A.D., Catania, V.A. Drug Metab. Dispos. (2006) [Pubmed]
  20. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Liu, J., Chen, H., Miller, D.S., Saavedra, J.E., Keefer, L.K., Johnson, D.R., Klaassen, C.D., Waalkes, M.P. Mol. Pharmacol. (2001) [Pubmed]
  21. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. Cao, J., Stieger, B., Meier, P.J., Vore, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
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