The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Pi4kb  -  phosphatidylinositol 4-kinase, catalytic,...

Rattus norvegicus

Synonyms: PI4K-beta, PI4Kbeta, Phosphatidylinositol 4-kinase beta, Pik4cb, PtdIns 4-kinase beta
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Pik4cb

  • Additionally, the overexpression of mutated NCS-1 prevents the stimulatory effect on secretion induced by PI4K-beta, suggesting that the interaction of the two proteins on a membrane compartment is necessary for the secretory function [1].
  • Moreover, extinction of endogenous PI4K-beta by small interfering RNA inhibits secretion and completely prevents the stimulatory effect of NCS-1 on calcium-evoked exocytosis from permeabilized PC12 cells, showing directly for the first time the functional implication of a NCS-1.PI4K-beta complex in regulated exocytosis [1].
  • In contrast, PtdIns 4-kinase beta accumulated on the distal side which suggests that it undergoes retrograde axonal transport and unlike NCS-1 was also present in non-neuronal cells [2].
 

Anatomical context of Pik4cb

 

Analytical, diagnostic and therapeutic context of Pik4cb

References

  1. Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells. de Barry, J., Janoshazi, A., Dupont, J.L., Procksch, O., Chasserot-Golaz, S., Jeromin, A., Vitale, N. J. Biol. Chem. (2006) [Pubmed]
  2. Axonal transport of neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta in the adult rat sciatic nerve. Reynolds, A.J., Hendry, I.A., Bartlett, S.E. Neuroreport (2000) [Pubmed]
  3. Alterations in exocytosis induced by neuronal Ca2+ sensor-1 in bovine chromaffin cells. Pan, C.Y., Jeromin, A., Lundstrom, K., Yoo, S.H., Roder, J., Fox, A.P. J. Neurosci. (2002) [Pubmed]
 
WikiGenes - Universities