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Gene Review

PIP2B  -  aquaporin PIP2-2

Arabidopsis thaliana

Synonyms: PIP2;2, PLASMA MEMBRANE INTRINSIC PROTEIN 2;2, T2N18.7, T2N18_7, plasma membrane intrinsic protein 2
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Disease relevance of PIP2B

  • Two independent Arabidopsis knockout mutants of PIP2;2 were isolated using a PCR-based strategy from a library of plant lines mutagenized by the insertion of Agrobacterium tumefaciens T-DNA [1].

High impact information on PIP2B

  • Matrix-assisted laser desorption/ionization time-of-flight analyses suggested that Plasma Membrane Intrinsic Protein2;2 (PIP2;2) is one of the abundantly expressed aquaporin isoforms in Arabidopsis root plasma membranes [1].
  • The phenotype of PIP2;2 mutants demonstrates that, despite their high homology and isoform multiplicity, plant aquaporins have evolved with nonredundant functions [1].
  • Expression in transgenic Arabidopsis of a PIP2;2 promoter-beta-glucuronidase gene fusion indicated that PIP2;2 is expressed predominantly in roots, with a strong expression in the cortex, endodermis, and stele [1].
  • PIP2;2 has a close homolog, PIP2;3, showing 96.8% amino acid identity [1].

Other interactions of PIP2B

  • Together, our data provide evidence for the contribution of a single aquaporin gene to root water uptake and identify PIP2;2 as an aquaporin specialized in osmotic fluid transport [1].


  1. Role of a single aquaporin isoform in root water uptake. Javot, H., Lauvergeat, V., Santoni, V., Martin-Laurent, F., Güçlü, J., Vinh, J., Heyes, J., Franck, K.I., Schäffner, A.R., Bouchez, D., Maurel, C. Plant Cell (2003) [Pubmed]
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