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Gene Review

RD28  -  aquaporin PIP2-3

Arabidopsis thaliana

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Disease relevance of RD28

  • These MIPs include clone 7a from pea and RD28 from Arabidopsis, both of which are water-stress proteins, a tomato ripening-associated membrane protein, and PIP 2b, a PM-bound water channel protein from Arabidopsis [1].

High impact information on RD28

  • PIP2;2 has a close homolog, PIP2;3, showing 96.8% amino acid identity [2].
  • Transformants contained RD28 protein in their plasma membranes [3].
  • To find out if RD28 is a water channel protein, rd28 cRNA was injected into Xenopus laevis oocytes [4].
  • Although RD28 has several cysteine residues, its activity is not inhibited by mercury, and in this respect it differs from gamma-TIP and all but one of the mammalian water channels that have been described [4].
  • Expression of RD28 caused a 10- to 15-fold increase in the osmotic water permeability of the oocytes, indicating that the protein creates water channels in the plasma membrane of the oocytes and is an aquaporin just like its homology gamma-TIP [4].


  1. Plasma membrane intrinsic proteins of Beta vulgaris L. Qi, X., Tai, C.Y., Wasserman, B.P. Plant Physiol. (1995) [Pubmed]
  2. Role of a single aquaporin isoform in root water uptake. Javot, H., Lauvergeat, V., Santoni, V., Martin-Laurent, F., Güçlü, J., Vinh, J., Heyes, J., Franck, K.I., Schäffner, A.R., Bouchez, D., Maurel, C. Plant Cell (2003) [Pubmed]
  3. Expression of an Arabidopsis plasma membrane aquaporin in Dictyostelium results in hypoosmotic sensitivity and developmental abnormalities. Chaumont, F., Loomis, W.F., Chrispeels, M.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. The plasma membrane of Arabidopsis thaliana contains a mercury-insensitive aquaporin that is a homolog of the tonoplast water channel protein TIP. Daniels, M.J., Mirkov, T.E., Chrispeels, M.J. Plant Physiol. (1994) [Pubmed]
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