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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LZTR1  -  leucine-zipper-like transcription regulator 1

Homo sapiens

Synonyms: BTBD29, LZTR-1, Leucine-zipper-like transcriptional regulator 1, SWNTS2, TCFL2
 
 
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Disease relevance of LZTR1

  • The BTB-kelch protein LZTR-1 is deleted in the majority of DiGeorge syndrome patients and is believed to act as a transcriptional regulator [1].
 

High impact information on LZTR1

  • Although LZTR-1 does not locate in the shortest region of overlap, several of its structural characteristics identifying it as transcriptional regulator suggest that it plays a crucial role in embryogenesis and that haploinsufficiency of this gene may be partly related to the development of DGS [2].
  • Treatment with brefeldin A did not lead to redistribution of LZTR-1 to the endoplasmic reticulum but caused its relocalization in dispersed, punctuated structures that were also positive for GM130 [1].
  • The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis [1].
  • Taken together, our experiments identify LZTR-1 as the first BTB-kelch protein that exclusively localizes to the Golgi network, and the binding of LZTR-1 to the Golgi complex is mediated by its second BTB/POZ domain [1].
  • Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006 [3].
 

Associations of LZTR1 with chemical compounds

  • Upon induction of apoptosis, LZTR-1 was phosphorylated on tyrosine residues and subsequently degraded; that could be rescued partially by the addition of the caspase inhibitor Z-VAD-fmk and the proteasome inhibitors lactacystin and MG132 [1].

References

  1. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. Nacak, T.G., Leptien, K., Fellner, D., Augustin, H.G., Kroll, J. J. Biol. Chem. (2006) [Pubmed]
  2. Isolation and characterization of a novel gene deleted in DiGeorge syndrome. Kurahashi, H., Akagi, K., Inazawa, J., Ohta, T., Niikawa, N., Kayatani, F., Sano, T., Okada, S., Nishisho, I. Hum. Mol. Genet. (1995) [Pubmed]
  3. Transcription factor 7-like 2 (TCFL2) - a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nature Genetics 2006, Published online 15 January 2006. Kiessling, A., Ehrhart-Bornstein, M. Horm. Metab. Res. (2006) [Pubmed]
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