Gene Review:
TCF7L2 - transcription factor 7-like 2 (T-cell...
Homo sapiens
Synonyms:
HMG box transcription factor 4, T-cell factor 4, T-cell-specific transcription factor 4, TCF-4, TCF4, ...
Duren,
Grant,
Hamlington,
Leach,
Guralnik,
Thorsteinsdottir,
Mohlke,
Göran Berglund,
Melzer,
Wilensky,
Antje Körner,
Murray,
Sutter,
Duggirala,
Schmutzler,
Christiansen,
Helgadottir,
Rita Mancarella,
Roberto Lupi,
Leif Groop,
Sainz,
Marketa Sjögren,
Janin Berndt,
Willer,
Göring,
Magnusson,
Benediktsson,
Gylfason,
Meindl,
Reilly,
Burwinkel,
Sprau,
Bagger,
Paolisso,
Gulcher,
Kiechle,
Hurst,
Sigurdsson,
Narisu,
Bartram,
Shanmugam,
Marju Orho-Melander,
Chines,
Corsi,
Boehnke,
Palsdottir,
Stringham,
Silvia Del Guerra,
Tiinamaija Tuomi,
Charlotte Ling,
Thorleifsson,
Helgason,
Michael Stumvoll,
Valeriya Lyssenko,
Stefansson,
Ferrucci,
Kong,
Reynisdottir,
Scott,
Blangero,
Bonnycastle,
Gudmundsdottir,
Frayling,
Peter Kovacs,
Piero Marchetti,
Asa-Linda Lethagen,
Rader,
Jackson,
Wappenschmidt,
Walters,
Abboud,
Valle,
Collins,
Wieland Kiess,
Tuomilehto,
Stern,
Peter Almgren,
Peter Nilsson,
Arya,
Stefansson,
Hunt,
Stefano Del Prato,
Karl-Fredrik Eriksson,
Manolescu,
Lehman,
Weedon,
Jonsdottir,
Emilsson,
Bergman,
Hemminki,
Erdos,
Bandinelli,
Frank,
Gudnason,
Styrkarsdottir,
Saemundsdottir,
- Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study. Burwinkel, B., Shanmugam, K.S., Hemminki, K., Meindl, A., Schmutzler, R.K., Sutter, C., Wappenschmidt, B., Kiechle, M., Bartram, C.R., Frank, B. BMC Cancer (2006)
- TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population: The Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study. Cauchi, S., Meyre, D., Choquet, H., Dina, C., Born, C., Marre, M., Balkau, B., Froguel, P. Diabetes (2006)
- Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Chandak, G.R., Janipalli, C.S., Bhaskar, S., Kulkarni, S.R., Mohankrishna, P., Hattersley, A.T., Frayling, T.M., Yajnik, C.S. Diabetologia (2007)
- Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Kaidi, A., Williams, A.C., Paraskeva, C. Nat. Cell Biol. (2007)
- Colorectal cancer and genetic alterations in the Wnt pathway. Segditsas, S., Tomlinson, I. Oncogene (2006)
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Grant, S.F., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., Styrkarsdottir, U., Magnusson, K.P., Walters, G.B., Palsdottir, E., Jonsdottir, T., Gudmundsdottir, T., Gylfason, A., Saemundsdottir, J., Wilensky, R.L., Reilly, M.P., Rader, D.J., Bagger, Y., Christiansen, C., Gudnason, V., Sigurdsson, G., Thorsteinsdottir, U., Gulcher, J.R., Kong, A., Stefansson, K. Nat. Genet. (2006)
- Crystal Structure of a beta-Catenin/BCL9/Tcf4 Complex. Sampietro, J., Dahlberg, C.L., Cho, U.S., Hinds, T.R., Kimelman, D., Xu, W. Mol. Cell (2006)
- Involvement of Splicing Factor-1 in beta-Catenin/T-Cell Factor-4-Mediated Gene Transactivation and Pre-mRNA Splicing. Shitashige, M., Naishiro, Y., Idogawa, M., Honda, K., Ono, M., Hirohashi, S., Yamada, T. Gastroenterology (2007)
- Tcf4 can specifically recognize beta-catenin using alternative conformations. Graham, T.A., Ferkey, D.M., Mao, F., Kimelman, D., Xu, W. Nat. Struct. Biol. (2001)
- Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3. Duval, A., Busson-Leconiat, M., Berger, R., Hamelin, R. Cytogenet. Cell Genet. (2000)
- Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. Humphries, S.E., Gable, D., Cooper, J.A., Ireland, H., Stephens, J.W., Hurel, S.J., Li, K.W., Palmen, J., Miller, M.A., Cappuccio, F.P., Elkeles, R., Godsland, I., Miller, G.J., Talmud, P.J. J. Mol. Med. (2006)
- Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Shulewitz, M., Soloviev, I., Wu, T., Koeppen, H., Polakis, P., Sakanaka, C. Oncogene (2006)
- Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human {beta}-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes. Cauchi, S., Meyre, D., Dina, C., Choquet, H., Samson, C., Gallina, S., Balkau, B., Charpentier, G., Pattou, F., Stetsyuk, V., Scharfmann, R., Staels, B., Fr??hbeck, G., Froguel, P. Diabetes (2006)
- BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Bonafede, A., K??hler, T., Rodriguez-Niedenf??hr, M., Brand-Saberi, B. Dev. Biol. (2006)
- Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes. Rossi, A., Mukerjee, R., Ferrante, P., Khalili, K., Amini, S., Sawaya, B.E. J. Gen. Virol. (2006)
- Haplotypes of Transcription Factor 7-Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans. Lehman, D.M., Hunt, K.J., Leach, R.J., Hamlington, J., Arya, R., Abboud, H.E., Duggirala, R., Blangero, J., Göring, H.H., Stern, M.P. Diabetes (2007)
- Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. Lyssenko, V., Lupi, R., Marchetti, P., Del Guerra, S., Orho-Melander, M., Almgren, P., Sjögren, M., Ling, C., Eriksson, K.F., Lethagen, A.L., Mancarella, R., Berglund, G., Tuomi, T., Nilsson, P., Del Prato, S., Groop, L. J. Clin. Invest. (2007)
- TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children. Körner, A., Berndt, J., Stumvoll, M., Kiess, W., Kovacs, P. J. Clin. Endocrinol. Metab. (2007)
- Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Schäfer, S.A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J.J., Dekker, J.M., 't Hart, L.M., t'Hart, L.M., Nijpels, G., van Haeften, T.W., Häring, H.U., Fritsche, A. Diabetologia (2007)
- Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. Melzer, D., Murray, A., Hurst, A.J., Weedon, M.N., Bandinelli, S., Corsi, A.M., Ferrucci, L., Paolisso, G., Guralnik, J.M., Frayling, T.M. BMC medicine (2006)
- Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. Weedon, M.N., McCarthy, M.I., Hitman, G., Walker, M., Groves, C.J., Zeggini, E., Rayner, N.W., Shields, B., Owen, K.R., Hattersley, A.T., Frayling, T.M. PLoS Med. (2006)
- Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Scott, L.J., Bonnycastle, L.L., Willer, C.J., Sprau, A.G., Jackson, A.U., Narisu, N., Duren, W.L., Chines, P.S., Stringham, H.M., Erdos, M.R., Valle, T.T., Tuomilehto, J., Bergman, R.N., Mohlke, K.L., Collins, F.S., Boehnke, M. Diabetes (2006)
- Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. Tzeng, S.L., Cheng, Y.W., Li, C.H., Lin, Y.S., Hsu, H.C., Kang, J.J. J. Biol. Chem. (2006)